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[肌肉松弛时大鼠骨骼肌和心肌中的腺嘌呤核苷酸及磷酸肌酸水平]

[Adenine nucleotide and creatine phosphate levels in rat skeletal muscles and myocardium in myorelaxation].

作者信息

Krapivina O V

出版信息

Ukr Biokhim Zh (1978). 1985 Jul-Aug;57(4):70-2.

PMID:4035798
Abstract

The content of adenylic system components and creatine phosphate was determined in skeletal muscles and myocardium after intraperitoneal injection and short-term action of myorelaxin and arduan. The injected myorelaxin causes no significant changes in macroergic phosphates in skeletal muscles, whereas arduan lowers the ATP amount by 39%. The both myorelaxants have the same effect on the adenylic system components of the myocardium: they lower significantly the level of ATP and enhance that of ADP and AMP. Different variational tendences of variation in the content of creatine phosphate in skeletal muscles (a certain rise) and in the myocardium (a decrease more than by 30%) are observed.

摘要

在腹腔注射肌松弛素和阿端并使其短期作用后,测定了骨骼肌和心肌中腺苷酸系统成分及磷酸肌酸的含量。注射的肌松弛素对骨骼肌中高能磷酸盐无显著影响,而阿端使三磷酸腺苷(ATP)含量降低了39%。两种肌松药对心肌腺苷酸系统成分的作用相同:它们显著降低ATP水平,提高二磷酸腺苷(ADP)和一磷酸腺苷(AMP)水平。观察到骨骼肌中磷酸肌酸含量有一定升高,而心肌中磷酸肌酸含量下降超过30%,呈现出不同的变化趋势。

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