Baev V I, Drukina M A
Vopr Med Khim. 1976 Jan-Feb;22(1):37-41.
In experiments with rats, subjected to single and repeated simultaneous effect of hypercapnia, hypoxia and cooling, contents of pyridine nucleotides (NAD, NADP, NAD-H2 and NADP-H2) and macroergic substances were studied and also the activity of dehydrogenases of the pentose pathway was determined in brain and myocardium. In brain NADP was not practically determined and in heart its content was increased after the first and the second treatments. Content of NADP-H2 was distinctly decreased in both tissues after the single treatment. NAD was not altered in the tissues in all the periods studied. The amount of NAD-H2 was decreased in brain after the single treatment and it was increased in myocardium after the repeated one. In the activity of dehydrogenases marked alterations were not observed. Total macroergic substances were not altered in brain after the single treatment and after the repeated one they were increased mainly due to the ATP increase. In myocardium total macroergic substances were decreased after the both treatments.
在对大鼠进行的实验中，使其遭受高碳酸血症、缺氧和冷却的单次及重复同时作用，研究了吡啶核苷酸（NAD、NADP、NAD - H2和NADP - H2）和高能物质的含量，并测定了脑和心肌中戊糖途径脱氢酶的活性。在脑中实际上未检测到NADP，而在心脏中，第一次和第二次处理后其含量增加。单次处理后，两种组织中NADP - H2的含量均明显降低。在所研究的所有时期，组织中的NAD均未改变。单次处理后脑中NAD - H2的量减少，而重复处理后心肌中的NAD - H2增加。脱氢酶的活性未观察到明显变化。单次处理后脑中总高能物质未改变，重复处理后主要由于ATP增加而增加。两种处理后心肌中的总高能物质均减少。
