纳米颗粒大小对体内药代动力学和细胞相互作用的影响。
The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction.
作者信息
Hoshyar Nazanin, Gray Samantha, Han Hongbin, Bao Gang
机构信息
Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA.
Department of Radiology, Peking University Third Hospital, Beijing 100191, China.
出版信息
Nanomedicine (Lond). 2016 Mar;11(6):673-92. doi: 10.2217/nnm.16.5. Epub 2016 Mar 22.
Abstract
Nanoparticle-based technologies offer exciting new approaches to disease diagnostics and therapeutics. To take advantage of unique properties of nanoscale materials and structures, the size, shape and/or surface chemistry of nanoparticles need to be optimized, allowing their functionalities to be tailored for different biomedical applications. Here we review the effects of nanoparticle size on cellular interaction and in vivo pharmacokinetics, including cellular uptake, biodistribution and circulation half-life of nanoparticles. Important features of nanoparticle probes for molecular imaging and modeling of nanoparticle size effects are also discussed.
摘要
基于纳米颗粒的技术为疾病诊断和治疗提供了令人兴奋的新方法。为了利用纳米级材料和结构的独特性质，需要优化纳米颗粒的尺寸、形状和/或表面化学性质，以便针对不同的生物医学应用定制其功能。在这里，我们综述了纳米颗粒尺寸对细胞相互作用和体内药代动力学的影响，包括纳米颗粒的细胞摄取、生物分布和循环半衰期。还讨论了用于分子成像的纳米颗粒探针的重要特征以及纳米颗粒尺寸效应的建模。
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