Department of Oral and Maxillofacial Pathology, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Inflamm Res. 2021 May;70(5):509-524. doi: 10.1007/s00011-021-01448-z. Epub 2021 Mar 5.
Several epidemiological studies have evaluated association of interleukin 10 (IL-10) polymorphisms with risk of periodontitis. However, the results remain conflicting and inconclusive. Here, we carried out a comprehensive systematic review and meta-analysis to evaluate the association of IL-10 -1082A>G, -819C>T, and -592C>A polymorphisms with risk of chronic (CP) and aggressive (CP) periodontitis.
Electronic databases including PubMed, Science Direct, SciELO, and CNKI were systematically searched to identify all relevant studies published up to 01 June 2020.
A total of 60 case-control studies with 5313 cases and 6528 controls met our inclusion criteria. Overall, the pooled data showed that the IL-10 -592C>A polymorphism was statistically associated with increased risk of periodontitis in the overall population, while no significant association was identified for IL-10 -1082A>G and IL-10 -819C>T polymorphisms. The subgroup analysis by ethnicity revealed that the IL-10 -1082A>G polymorphism was significantly associated with periodontitis risk in Caucasians, IL-10 -819C>T polymorphism in mixed population, and IL-10 -592C>A polymorphism in both Asians and mixed populations. When further analyzed by periodontitis type, only the IL-10 -592C>A polymorphism was associated with CP risk, but not AgP; and the IL-10 -1082A>G and -819C>T polymorphisms have not positive association neither in the CP and AgP.
The current meta-analysis showed that the IL-10 -592C>A polymorphism was statistically associated with periodontitis risk in the overall population. Moreover, the IL-10 -1082A>G, IL-10 -819C>T, and IL-10 -592C>A polymorphisms were associated with periodontitis risk by ethnicity. Therefore, the IL-10 polymorphisms are of high clinical relevance by ethnicity and would be a useful marker to identify patients who are at higher risk for periodontitis.
多项流行病学研究评估了白细胞介素 10（IL-10）多态性与牙周炎风险的关联。然而，结果仍存在争议且不一致。在此，我们进行了一项全面的系统评价和荟萃分析，以评估 IL-10-1082A>G、-819C>T 和-592C>A 多态性与慢性（CP）和侵袭性（AgP）牙周炎风险的关联。
系统检索了 PubMed、Science Direct、SciELO 和中国知网（CNKI）等电子数据库，以识别截至 2020 年 6 月 1 日发表的所有相关研究。
共有 60 项病例对照研究，包括 5313 例病例和 6528 例对照，符合纳入标准。总体而言，汇总数据显示，IL-10-592C>A 多态性与总体人群牙周炎风险增加相关，而 IL-10-1082A>G 和 IL-10-819C>T 多态性与牙周炎风险无关。按种族进行的亚组分析显示，IL-10-1082A>G 多态性与白种人牙周炎风险显著相关，IL-10-819C>T 多态性与混合人群相关，IL-10-592C>A 多态性与亚洲人和混合人群均相关。当进一步按牙周炎类型进行分析时，仅 IL-10-592C>A 多态性与 CP 风险相关，而非 AgP；且 IL-10-1082A>G 和-819C>T 多态性在 CP 和 AgP 中均无阳性关联。
本荟萃分析显示，IL-10-592C>A 多态性与总体人群牙周炎风险相关。此外，IL-10-1082A>G、IL-10-819C>T 和 IL-10-592C>A 多态性与种族相关的牙周炎风险相关。因此，IL-10 多态性具有高度的临床相关性，且具有种族差异，是一种有助于识别牙周炎高危患者的有用标志物。
