Watanabe Taku, Tsujino Ichizo, Konno Satoshi, Ito Yoichi M, Takashina Chisa, Sato Takahiro, Isada Akira, Ohira Hiroshi, Ohtsuka Yoshinori, Fukutomi Yuma, Nakamura Hiroyuki, Kawagishi Yukio, Okada Chiharu, Hizawa Nobuyuki, Taniguchi Masami, Akasawa Akira, Nishimura Masaharu
First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan.
Department of Biostatistics, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
PLoS One. 2016 Mar 23;11(3):e0148926. doi: 10.1371/journal.pone.0148926. eCollection 2016.
A positive association between the number of cigarettes smoked per day and obesity has been reported, whereas how other smoking-related indices, such as pack-years and duration of smoking, are related with obesity has been less investigated. We analyzed the age-adjusted cross-sectional association between smoking and obesity in a general Japanese population.
We used data from a nationwide epidemiological study of Japanese adults (N = 23,106). We compared the prevalence of obesity (defined as body mass index ≥ 25kg/m2) among groups classified by smoking behavior, pack-years, number of cigarettes per day, duration of smoking, and duration and time of smoking cessation.
In men, current smokers had a lower odds ratio (OR) for obesity of 0.80 (95% confidence interval (CI): 0.72-0.88) compared to non-smokers, whereas past smokers had a higher OR of 1.23 (95% CI: 1.09-1.37) compared to current smokers. In women, there were no differences in obesity between the three groups classified by smoking behavior. However, in both sexes, the prevalence of obesity tended to increase with pack-years and the number of cigarettes per day, but not with duration of smoking in current and past smokers. Further, in male smokers, the risks for obesity were markedly higher in short-term heavy smokers compared with long-term light smokers, even with the same number of pack-years. Regarding the impact of smoking cessation, female past smokers who quit smoking at an age > 55-years had an elevated OR of 1.60 (95% CI:1.05-2.38) for obesity.
In a general Japanese population, obesity is progressively associated with pack-years and number of cigarettes per day, but not with the duration of smoking. When investigating the association between obesity and cigarette smoking, the daily smoking burden and the duration of smoking require to be independently considered.
据报道，每日吸烟量与肥胖之间存在正相关，而其他与吸烟相关的指标，如吸烟包年数和吸烟持续时间，与肥胖之间的关系则较少被研究。我们分析了日本普通人群中吸烟与肥胖之间经年龄调整的横断面关联。
我们使用了一项针对日本成年人的全国性流行病学研究的数据（N = 23106）。我们比较了根据吸烟行为、吸烟包年数、每日吸烟量、吸烟持续时间以及戒烟持续时间和时间分类的各组中肥胖（定义为体重指数≥25kg/m²）的患病率。
在男性中，与不吸烟者相比，当前吸烟者肥胖的优势比（OR）为较低的0.80（95%置信区间（CI）：0.72 - 0.88），而既往吸烟者与当前吸烟者相比，OR较高，为1.23（95% CI：1.09 - 1.37）。在女性中，根据吸烟行为分类的三组之间肥胖患病率没有差异。然而，在两性中，肥胖患病率均倾向于随着吸烟包年数和每日吸烟量的增加而升高，但在当前和既往吸烟者中，与吸烟持续时间无关。此外，在男性吸烟者中，即使吸烟包年数相同，短期重度吸烟者肥胖的风险也明显高于长期轻度吸烟者。关于戒烟的影响，在55岁以后戒烟的女性既往吸烟者肥胖的OR升高至1.60（95% CI：1.05 - 2.38）。
在日本普通人群中，肥胖与吸烟包年数和每日吸烟量呈逐步相关，但与吸烟持续时间无关。在研究肥胖与吸烟之间的关联时，需要独立考虑每日吸烟负担和吸烟持续时间。
