Sennerby L, Lekholm U, Ericson L E
Int J Oral Maxillofac Implants. 1989 Fall;4(3):233-9.
Clinically retrieved titanium implant cover screws (Brånemark implant system), rinsed in saline or subjected to ultrasonic cleaning and sterilization, as well as unused sterile screws were studied by scanning electron microscopy and implanted in the rat abdominal wall for 6 weeks. Irrespective of cleaning procedure, the heads of the clinically retrieved screws were covered by numerous contaminants not present on the unused screws. The reimplanted screws elicited a different tissue response than the unused screws. The tissue response to the contaminated screws was characterized by a significantly thicker fibrous capsule and by a significantly larger number of macrophages located close to the implant. Moreover, judging from their ultrastructure, studied with transmission electron microscopy, the macrophages appeared to be in a more active state when compared to those located adjacent to unused screws.
对临床回收的钛种植体覆盖螺丝（Brånemark种植系统）进行研究，这些螺丝先用生理盐水冲洗，或经过超声清洗和灭菌处理，同时还研究了未使用的无菌螺丝。通过扫描电子显微镜对其进行观察，并将其植入大鼠腹壁6周。无论清洗程序如何，临床回收螺丝的头部都覆盖着大量未使用螺丝上不存在的污染物。重新植入的螺丝引发的组织反应与未使用的螺丝不同。对受污染螺丝的组织反应表现为纤维囊明显增厚，且靠近植入物处的巨噬细胞数量明显增多。此外，通过透射电子显微镜研究其超微结构发现，与未使用螺丝相邻处的巨噬细胞相比，这些巨噬细胞似乎处于更活跃的状态。
