Blazheevich N V, Spirichev V B, Pozdniakov A L
Vopr Pitan. 1978 May-Jun(3):19-27.
Keeping rats on a ration with a 1:3 proportion of calcium and phosphorus for 2 weeks results in hyperprosphatemia, hypocalcemia and renal calcinosis with uremia. When putting these animals on a food ration with the calcium and phosphorus ratio of 1:1 the concentration of these elements in the blood quickly returns back to normal, while renal calcinosis continues for the whole period of observation (7 months). The growing animals are more sensitive to a phosphorus excess than are the adult ones. An excessive consumption of phosphorus leads to its increased excretion with the urine with concurrent diminution of the calcium excretion. The blood and urine pH then experiences no change, whereas the ability of the turned inside out segments of the small intestine to absorb calcium as against the concentration gradient (active transport) in vitro not only does not diminish, but initially even goes up. It is suggested that the excess phosphorus content in the food ration tends to directly derange absorption of calcium in the intestines, this resulting in the development of hypocalciemia, hyperparathyroidism and calcinosis of the viscera and tissues.
让大鼠食用钙磷比例为1:3的日粮两周会导致高磷血症、低钙血症以及伴有尿毒症的肾钙化。当将这些动物置于钙磷比例为1:1的日粮中时，血液中这些元素的浓度会迅速恢复正常，而肾钙化在整个观察期（7个月）内持续存在。生长中的动物比成年动物对磷过量更为敏感。过量摄入磷会导致其随尿液排泄增加，同时钙排泄减少。血液和尿液的pH值随后无变化，而小肠外翻段在体外逆浓度梯度吸收钙（主动转运）的能力不仅不会降低，最初甚至还会增强。有人认为，日粮中过量的磷含量往往会直接扰乱肠道对钙的吸收，从而导致低钙血症、甲状旁腺功能亢进以及内脏和组织的钙化。
