Department of Internal Medicine, Namik Kemal University School of Medicine, Tekirdag, Turkey.
Eur Rev Med Pharmacol Sci. 2016 Mar;20(5):892-8.
Diabetic peripheral neuropathy is a common complication of type-2 diabetes mellitus. Endocan, apelin and endoglin are thought to be associated with endothelial dysfunction, angiogenesis and inflammation. In this study, we planned to evaluate these markers in diabetic peripheral neuropathy patients.
This single-blind, controlled clinical study was conducted on 99 type 2 diabetic patients with or without diabetic peripheral neuropathy and 53 healthy volunteer controls. Physical and laboratory examinations were done in all groups. In these groups, Endoglin, apelin and endocan levels were measured with ELISA method.
Endoglin, apelin and endocan concentrations in diabetic peripheral neuropathy patients were higher than other diabetes mellitus patients and healthy controls. Similarly, diabetes mellitus patient's endoglin, apelin and endocan levels were higher than healthy controls. The differences were statistically significant. We detected a significant positive correlation between endoglin, apelin and endocan levels in all groups.
Endoglin, apelin and endocan may reflect angiogenesis and endothelial dysfunction in diabetic peripheral neuropathy and they may be used as a marker in the future.
糖尿病周围神经病变是 2 型糖尿病的常见并发症。内脂素、apelin 和内皮糖蛋白被认为与血管内皮功能障碍、血管生成和炎症有关。在本研究中，我们计划评估这些标志物在糖尿病周围神经病变患者中的作用。
这是一项单盲、对照的临床研究，共纳入 99 例 2 型糖尿病患者（有或无糖尿病周围神经病变）和 53 名健康志愿者对照。所有组均进行体格检查和实验室检查。在这些组中，采用 ELISA 法测量内皮糖蛋白、apelin 和内脂素水平。
糖尿病周围神经病变患者的内皮糖蛋白、apelin 和内脂素浓度高于其他糖尿病患者和健康对照组。同样，糖尿病患者的内皮糖蛋白、apelin 和内脂素水平高于健康对照组。这些差异具有统计学意义。我们在所有组中均检测到内皮糖蛋白、apelin 和内脂素水平之间存在显著的正相关。
内皮糖蛋白、apelin 和内脂素可能反映了糖尿病周围神经病变中的血管生成和血管内皮功能障碍，它们可能在未来被用作标志物。
