Jena Prajna Parimita, Nanda Rachita, Ghosh Amritava, Patel Suprava, Shah Seema, Mohapatra Eli
Department of Biochemistry, All India Institute of Medical Sciences Raipur, GE Road, Tatibandh. Raipur, Raipur, Chhattisgarh, 492099, India.
Department of Endocrinology and Metabolism, All India Institute of Medical Sciences Raipur, Raipur, Chhattisgarh, 492099, India.
Sci Rep. 2025 Jan 5;15(1):850. doi: 10.1038/s41598-024-68790-0.
Diabetic peripheral neuropathy is a common complication of diabetes mellitus that has dire outcomes, affecting the economic profile of a country. Despite the multifactorial background of the pathogenesis of this disease, the mechanism underlying peripheral neuropathy is still unclear. Endothelial damage is a new determinant of pathogenesis, with endocan as a potential biomarker for endothelial dysfunction in diabetic peripheral neuropathy patients. In this cross-sectional study, with 49 patients with diabetes with peripheral neuropathy and 48 patients with diabetes without neuropathy, endothelial biomarkers such as endocan, hs-CRP, vitamin D, and lipid profiles were measured and analyzed in both groups. The standardized scores for dyslipidemia, inflammation, vitamin D and endocan were calculated. All of these biomarkers were significantly altered in peripheral neuropathy patients. A strong correlation between endocan levels and lipid profiles and between hs-CRP and vitamin D levels was detected. The inflammatory score and a combined score including all the above biomarkers might help in the early stratification of diabetic patients who are at greater risk of developing peripheral neuropathy.
糖尿病性周围神经病变是糖尿病的一种常见并发症，会产生严重后果，影响一个国家的经济状况。尽管该疾病发病机制具有多因素背景，但周围神经病变的潜在机制仍不清楚。内皮损伤是发病机制的一个新决定因素，内脂素作为糖尿病性周围神经病变患者内皮功能障碍的潜在生物标志物。在这项横断面研究中，对49例患有周围神经病变的糖尿病患者和48例无神经病变的糖尿病患者进行了研究，测量并分析了两组患者的内皮生物标志物，如内脂素、高敏C反应蛋白、维生素D和血脂谱。计算了血脂异常、炎症、维生素D和内脂素的标准化分数。所有这些生物标志物在周围神经病变患者中均有显著改变。检测到内脂素水平与血脂谱之间以及高敏C反应蛋白与维生素D水平之间存在强相关性。炎症评分以及包括上述所有生物标志物的综合评分可能有助于对发生周围神经病变风险较高的糖尿病患者进行早期分层。
