Yücel M, Kotan D, Gurol Çiftçi G, Çiftçi I H, Cikriklar H I
Department of Emergency Medicine, Sakarya University, Faculty of Medicine, Sakarya, Turkey.
Eur Rev Med Pharmacol Sci. 2016 Mar;20(5):930-6.
Endothelial dysfunction is involved in inflammatory disorders, migration, angiogenesis, and tumor progression. There is a known relationship between migraine and inflammation; however, there are conflicting data as to whether there is a link between migraine and endothelial dysfunction. The current study aimed to determine the relationships between migraine and levels of serum Endocan (ESM-1), Claudin-5 (CLDN5), IL-1β, IL-6 and TNF-α levels, which are proven indicators of endothelial dysfunction and inflammation in patients with migraine.
Thirty-one patients and 24 healthy subjects were included in this study. Participants underwent thorough physical and neurological evaluations, and levels of serum ESM-1, CLDN5, IL-1β, IL-6 and TNF-α were measured for each patient.
The levels of ESM-1, CLDN5, IL-1β, IL-6, and TNF-α were significantly higher in the migraine attack group than in the control group (p: 0.006, p: 0.002, p: 0.002, p: 0.003, p: 0.036, respectively). Additionally, there were significant differences in the ESM-1 levels of the visual analog scale (VAS) subgroup (p = 0.041), and there were moderate differences in the CLDN5 levels of the VAS subgroup (p = 0.064).
High serum levels of IL-1β, IL-6 and TNF-α in the migraine attack group indicate that inflammation plays a major role in migraine pathogenesis. In particular, the high ESM-1 and CLDN5 levels in patients with migraine suggest that inflammation should be investigated further, it may be a useful tool in the differential diagnosis of migraine.
内皮功能障碍与炎症性疾病、迁移、血管生成和肿瘤进展有关。偏头痛与炎症之间存在已知关联；然而，关于偏头痛与内皮功能障碍之间是否存在联系，数据存在冲突。本研究旨在确定偏头痛与血清内脂素（ESM-1）、紧密连接蛋白5（CLDN5）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平之间的关系，这些是偏头痛患者内皮功能障碍和炎症的已证实指标。
本研究纳入了31例患者和24名健康受试者。参与者接受了全面的体格和神经学评估，并测量了每位患者的血清ESM-1、CLDN5、IL-1β、IL-6和TNF-α水平。
偏头痛发作组的ESM-1、CLDN5、IL-1β、IL-6和TNF-α水平显著高于对照组（p值分别为0.006、0.002、0.002、0.003、0.036）。此外，视觉模拟量表（VAS）亚组的ESM-1水平存在显著差异（p = 0.041），VAS亚组的CLDN5水平存在中度差异（p = 0.064）。
偏头痛发作组血清中高水平的IL-1β、IL-6和TNF-α表明炎症在偏头痛发病机制中起主要作用。特别是，偏头痛患者中高水平的ESM-1和CLDN5表明应进一步研究炎症，它可能是偏头痛鉴别诊断的有用工具。
