Talandashti Mahtab Karami, Shahinfar Hossein, Delgarm Pedram, Jazayeri Shima
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Department of Nutrition, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran.
Neurol Sci. 2025 Feb;46(2):651-670. doi: 10.1007/s10072-024-07794-0. Epub 2024 Oct 15.
The existing evidence on the effect of dietary supplements for preventing migraines has generated conflicting results.
We assessed alterations in migraine clinical features corresponding to the intake of dietary supplements. Our main outcomes included the frequency (number of attacks), duration (in hours), the severity (intensity) and the monthly migraine days. Using a dose-response meta-analysis, we estimated the dose-dependent impact. The certainty of evidence was evaluated using the GRADE tool.
Finally, twenty-two trials were included in the systematic review and meta-analysis. Magnesium supplementation reduced migraine attacks (mean difference (MD) = -2.51), severity (MD = -0.88), and the monthly migraine days (MD = -1.66) compared with the control group. CoQ10 decreased the frequency (MD = -1.73), severity (MD = -1.35), and duration of migraine (MD = -1.72). Riboflavin decreased attack frequency (MD = -1.34). Alpha-lipoic acid decreased attack frequency (MD = -1.24) and severity (MD = -0.38). Probiotics decreased the frequency (MD = -1.16), severity (MD = -1.07) and the monthly migraine days (MD = -3.02). Vitamin D reduced migraine frequency (MD = -1.69) and the monthly migraine days (MD = -2.41). In adults, compared with placebo, these supplements did not significantly affect other outcomes, and omega-3 supplementation did not yield a statistically significant reduction in any of these outcomes.
The use of certain dietary supplements has resulted in a significant decrease in migraine prophylaxis. Further clinical trials of high quality appear to be beneficial.
关于膳食补充剂预防偏头痛效果的现有证据产生了相互矛盾的结果。
我们评估了与膳食补充剂摄入相对应的偏头痛临床特征变化。我们的主要结局包括发作频率（发作次数）、持续时间（小时数）、严重程度（强度）和每月偏头痛天数。使用剂量反应荟萃分析，我们估计了剂量依赖性影响。使用GRADE工具评估证据的确定性。
最后，22项试验纳入了系统评价和荟萃分析。与对照组相比，补充镁减少了偏头痛发作（平均差（MD）=-2.51）、严重程度（MD=-0.88）和每月偏头痛天数（MD=-1.66）。辅酶Q10降低了发作频率（MD=-1.73）、严重程度（MD=-1.35）和偏头痛持续时间（MD=-1.72）。核黄素降低了发作频率（MD=-1.34）。α-硫辛酸降低了发作频率（MD=-1.24）和严重程度（MD=-0.38）。益生菌降低了发作频率（MD=-1.16）、严重程度（MD=-1.07）和每月偏头痛天数（MD=-3.02）。维生素D降低了偏头痛频率（MD=-1.69）和每月偏头痛天数（MD=-2.41）。在成年人中，与安慰剂相比，这些补充剂对其他结局没有显著影响，补充ω-3对这些结局中的任何一项均未产生统计学上的显著降低。
使用某些膳食补充剂可显著降低偏头痛的预防效果。进一步开展高质量的临床试验似乎是有益的。
