Lee Nancy, Robinson Jennifer, Lu Helen
Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, United States.
Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, United States; Division of Orthodontics, College of Dental Medicine, Columbia University, New York, NY 10032, United States.
Curr Opin Biotechnol. 2016 Aug;40:64-74. doi: 10.1016/j.copbio.2016.03.006. Epub 2016 Mar 22.
The formation of multiple tissue types and their integration into composite tissue units presents a frontier challenge in regenerative engineering. Tissue-tissue synchrony is crucial in providing structural support for internal organs and enabling daily activities. This review highlights the state-of-the-art in composite tissue scaffold design, and explores how biomimicry can be strategically applied to avoid over-engineering the scaffold. Given the complexity of biological tissues, determining the most relevant parameters for recapitulating native structure-function relationships through strategic biomimicry will reduce the burden for clinical translation. It is anticipated that these exciting efforts in composite tissue engineering will enable integrative and functional repair of common soft tissue injuries and lay the foundation for total joint or limb regeneration.
多种组织类型的形成及其整合为复合组织单元是再生工程领域面临的前沿挑战。组织与组织之间的同步性对于为内部器官提供结构支撑以及实现日常活动至关重要。本综述重点介绍了复合组织支架设计的最新进展，并探讨了如何战略性地应用仿生学以避免对支架进行过度设计。鉴于生物组织的复杂性，通过战略性仿生学确定用于重现天然结构-功能关系的最相关参数将减轻临床转化的负担。预计在复合组织工程方面的这些令人振奋的努力将实现常见软组织损伤的整合性和功能性修复，并为全关节或肢体再生奠定基础。
