Le Donne Viviana, Crossland Nicholas, Brandão João, Sokolova Yuliya, Fowlkes Natalie, Nevarez Javier G, Langohr Ingeborg M, Gaunt Stephen D
Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.
Department of Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, USA.
Vet Clin Pathol. 2016 Jun;45(2):368-375. doi: 10.1111/vcp.12345. Epub 2016 Mar 23.
Chrysosporium-related infections have been increasingly reported in reptiles over the last 2 decades. In this report, we describe clinical, cytologic, histopathologic, and ultrastructural aspects of Chrysosporium-related infection in 2 Inland Bearded Dragons (Pogona vitticeps). Case 1 was presented for an enlarging raised lesion over the left eye and multiple additional masses over the dorsum. Case 2 was submitted to necropsy by the referring veterinarian for suspected yellow fungus disease. Impression smears of the nodules in case 1 revealed granulomatous to pyogranulomatous inflammation and many septate, variably long, 4-10 μm wide, often undulated hyphae, and very rare conidia. Postmortem impression smears of the superficial lesions of case 2 contained large numbers of solitary conidia and arthroconidia and low numbers of hyphae with similar morphology to case 1. Histopathology of the 2 cases revealed severe, multifocal, chronic, ulcerative, nodular pyogranulomatous dermatitis, with myriad intralesional septate hyphae, and arthroconidia. Fungal culture and molecular sequencing in both cases indicated infection with Nannizziopsis guarroi.
在过去20年里，与金孢子菌相关的感染在爬行动物中越来越多地被报道。在本报告中，我们描述了2只内陆鬃狮蜥（鬃狮蜥）与金孢子菌相关感染的临床、细胞学、组织病理学和超微结构特征。病例1因左眼出现一个不断增大的隆起病变以及背部有多个其他肿块前来就诊。病例2由转诊兽医提交尸检，怀疑患有黄真菌病。病例1结节的印片显示为肉芽肿性至脓性肉芽肿性炎症，有许多分隔、长短不一、宽4 - 10μm、常呈波浪状的菌丝，以及非常罕见的分生孢子。病例2浅表病变的死后印片含有大量单个分生孢子和关节孢子，菌丝数量较少，形态与病例1相似。这2例的组织病理学显示为严重的、多灶性、慢性、溃疡性、结节性脓性肉芽肿性皮炎，病灶内有大量分隔菌丝和关节孢子。两例的真菌培养和分子测序均表明感染了瓜氏南尼兹菌。
