Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Kyoto 607-8412, Japan.
Bioorg Med Chem. 2013 Mar 1;21(5):1043-9. doi: 10.1016/j.bmc.2013.01.012. Epub 2013 Jan 16.
A methanolic extract and its ethyl acetate-soluble fraction from Sri Lankan curry-leaf, the leaves of Murraya koenigii, inhibited melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. Two new carbazole alkaloids, karapinchamines A and B, were isolated from the ethyl acetate-soluble fraction together with 12 known carbazole alkaloids. The structures of karapinchamines A and B were determined by physicochemical analyses. The principal alkaloid constituents were found to display potent melanogenesis inhibitory activity. The structural requirements of the carbazole alkaloids for melanogenesis inhibitory activity were discussed.
从斯里兰卡咖喱叶（Murraya koenigii 的叶子）的甲醇提取物及其乙酸乙酯可溶部分中分离得到的两种新咔唑生物碱卡拉平查敏 A 和 B，以及 12 种已知的咔唑生物碱，可抑制茶碱刺激的小鼠 B16 黑素瘤 4A5 细胞中的黑色素生成。这些生物碱显示出很强的黑色素生成抑制活性。讨论了咔唑生物碱抑制黑色素生成活性的结构要求。
