Amsterdam Jay D, Panossian Alexander G
Depression Research Unit, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Research and Development Unit, Swedish Herbal Institute, Vallberga, Halland, Sweden.
Phytomedicine. 2016 Jun 15;23(7):770-83. doi: 10.1016/j.phymed.2016.02.009. Epub 2016 Feb 24.
Rhodiola rosea (R. rosea) is a botanical adaptogen with putative anti-stress and antidepressant properties. Evidence-based data supporting the effectiveness of R. rosea for depression in adults is limited, and therefore a comprehensive review of available animal and human studies suggesting a putative antidepressant action is warranted.
A review of the literature was undertaken to ascertain studies of possible antidepressant mechanisms of action and studies of the safety and effectiveness of R. rosea extracts in animals and adult humans.
A search of MEDLINE and the Russian state library database was conducted (up to October 2015) on R. rosea.
R. rosea extracts and its purified constituent, salidroside, has been shown to produce a variety of mediator interactions with several molecular networks of neuroendocrine-immune and neurotransmitter receptor systems likely to be involved in the pathophysiology of depression. A wide variety of preclinical in vivo and ex vivo studies with laboratory animals suggests the presence of several biochemical and pharmacological antidepressant-like actions.
Clinical assessment of R. rosea L. rhizome extracts in humans with various depressive syndromes is based upon results from two randomized, double-blind, placebo-controlled trials of 146 subjects with major depressive disorder and seven open-label studies totaling 714 individuals with stress-induced mild depression (diagnosed as asthenic syndrome or psychoneurosis). Overall, results of these studies suggests a possible antidepressant action for R. rosea extract in adult humans.
In contrast to most conventional antidepressants, R. rosea extract appears to be well-tolerated in short-term studies with a favorable safety profile.
R. rosea demonstrates multi-target effects on various levels of the regulation of cell response to stress, affecting various components of the neuroendocrine, neurotransmitter receptor and molecular networks associated with possible beneficial effects on mood.
红景天是一种植物适应原，具有假定的抗应激和抗抑郁特性。支持红景天对成人抑郁症有效性的循证数据有限，因此有必要对现有的动物和人体研究进行全面综述，这些研究提示了其假定的抗抑郁作用。
对文献进行综述，以确定关于红景天提取物在动物和成年人体内可能的抗抑郁作用机制、安全性及有效性的研究。
对MEDLINE和俄罗斯国家图书馆数据库进行检索（截至2015年10月），检索词为红景天。
红景天提取物及其纯化成分红景天苷已显示出与神经内分泌 - 免疫和神经递质受体系统的多个分子网络产生多种介质相互作用，这些系统可能参与抑郁症的病理生理学过程。对实验动物进行的大量临床前体内和体外研究表明存在多种生化和药理学上类似抗抑郁的作用。
对患有各种抑郁综合征的人类进行红景天根茎提取物的临床评估基于两项针对146名重度抑郁症患者的随机、双盲、安慰剂对照试验以及七项共714名应激性轻度抑郁症患者（诊断为虚弱综合征或精神神经症）的开放标签研究结果。总体而言，这些研究结果提示红景天提取物对成年人类可能具有抗抑郁作用。
与大多数传统抗抑郁药相比，在短期研究中红景天提取物似乎耐受性良好，安全性良好。
红景天对细胞对应激反应调节的各个层面具有多靶点作用，影响神经内分泌、神经递质受体以及与情绪可能的有益作用相关的分子网络的各个组成部分。
