内源性衰老对真皮-表皮交界处蛋白质组成的影响。
The impact of intrinsic ageing on the protein composition of the dermal-epidermal junction.
作者信息
Langton Abigail K, Halai Poonam, Griffiths Christopher E M, Sherratt Michael J, Watson Rachel E B
机构信息
Centre for Dermatology Research, Institute of Inflammation & Repair, Manchester Academic Health Science Centre, The University of Manchester, UK; The Dermatology Centre, Salford Royal NHS Foundation Trust, Salford, UK.
Centre for Tissue Injury and Repair, Institute of Inflammation & Repair, Manchester Academic Health Science Centre, The University of Manchester, UK.
出版信息
Mech Ageing Dev. 2016 Jun;156:14-6. doi: 10.1016/j.mad.2016.03.006. Epub 2016 Mar 21.
The dermal-epidermal junction of human skin exhibits age-related remodelling, resulting in a flattened appearance and reduced surface area. Despite this, a paucity of information is available regarding which protein components change with advancing age. Here we report a significant reduction in the protein distribution of collagen IV (P<0.0001), collagen VII (P<0.001), collagen XVII (P<0.01), integrin β4 (P<0.001) and laminin-332 (P<0.0001) in intrinsically aged skin. The functional implication of this altered protein composition appears to be loss of structural integrity and may, in part, explain the increased fragility of aged skin.
人类皮肤的真皮-表皮交界处呈现出与年龄相关的重塑，导致外观变平且表面积减小。尽管如此，关于哪些蛋白质成分会随着年龄增长而变化的信息却很少。在此，我们报告在自然老化的皮肤中，IV型胶原蛋白（P<0.0001）、VII型胶原蛋白（P<0.001）、XVII型胶原蛋白（P<0.01）、整合素β4（P<0.001）和层粘连蛋白-332（P<0.0001）的蛋白质分布显著减少。这种蛋白质组成改变的功能影响似乎是结构完整性的丧失，并且可能部分解释了老化皮肤脆弱性增加的原因。
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