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全株植物的植物化学特征及其活性成分的药妆和皮肤病学特性

: Phytochemical Profile and the Cosmeceutical and Dermatological Properties of Its Active Fraction from the Whole Plant.

作者信息

Wu Xing, Wanyan Meng-Fei, Shi Bao-Bao, Huang Rong, Yang Hui-Xiang, Wang Xian, Liu Ji-Kai

机构信息

Anhui Province Key Laboratory of Bioactive Natural Products, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.

School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.

出版信息

Molecules. 2025 Jan 14;30(2):311. doi: 10.3390/molecules30020311.

DOI:10.3390/molecules30020311
PMID:39860181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11767586/
Abstract

Natural products and botanicals continue to play a very important role in the development of cosmetics worldwide. The chemical constituents of a fine active fraction of the whole plant extract of Walp., and the tyrosinase and matrix metalloproteinase-1 (MMP-1) inhibitory and antioxidant activities of this fraction were investigated. The fine active fraction was mainly composed of seven natural compounds. The fine active fraction demonstrated substantial in vitro antioxidant potential using the ABTS assay (IC 1.66 μg/mL). It inhibited the two target enzymes (tyrosinase and MMP-1) engaged in skin whitening and aging with comparable IC values to the reference drugs. Acute toxicity experiments showed that mice gavage orally with the fine active fraction had no significant animal toxicity at a dose of 2000 mg/kg, and the maximum tolerated dose (MTD) in mice was greater than 2000 mg/kg. In a model where ultraviolet light promotes the increase in melanin secretion in guinea pig skin tissues, both α-arbutin and the fine active fraction can reduce melanogenesis, and the effect of the fine active fraction is better than that of α-arbutin.

摘要

天然产物和植物药在全球化妆品的发展中继续发挥着非常重要的作用。对Walp.全株提取物的精细活性成分的化学成分，以及该成分的酪氨酸酶和基质金属蛋白酶-1（MMP-1）抑制活性和抗氧化活性进行了研究。该精细活性成分主要由七种天然化合物组成。使用ABTS法（IC为1.66μg/mL），该精细活性成分在体外显示出显著的抗氧化潜力。它对参与皮肤美白和衰老的两种靶酶（酪氨酸酶和MMP-1）具有抑制作用，其IC值与参考药物相当。急性毒性实验表明，以2000mg/kg的剂量给小鼠口服灌胃该精细活性成分，未观察到明显的动物毒性，小鼠的最大耐受剂量（MTD）大于2000mg/kg。在紫外线促进豚鼠皮肤组织中黑色素分泌增加的模型中，α-熊果苷和该精细活性成分均可减少黑色素生成，且该精细活性成分的效果优于α-熊果苷。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1aa/11767586/2eb4c3a0f98c/molecules-30-00311-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1aa/11767586/3551645513f5/molecules-30-00311-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1aa/11767586/268ee1a226d5/molecules-30-00311-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1aa/11767586/9279fc112996/molecules-30-00311-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1aa/11767586/478c44ca407e/molecules-30-00311-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1aa/11767586/4423104dea07/molecules-30-00311-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1aa/11767586/3c08b7d02fee/molecules-30-00311-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1aa/11767586/2eb4c3a0f98c/molecules-30-00311-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1aa/11767586/3551645513f5/molecules-30-00311-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1aa/11767586/268ee1a226d5/molecules-30-00311-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1aa/11767586/9279fc112996/molecules-30-00311-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1aa/11767586/478c44ca407e/molecules-30-00311-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1aa/11767586/4423104dea07/molecules-30-00311-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1aa/11767586/3c08b7d02fee/molecules-30-00311-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1aa/11767586/2eb4c3a0f98c/molecules-30-00311-g007.jpg

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本文引用的文献

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Front Physiol. 2023 Nov 22;14:1297637. doi: 10.3389/fphys.2023.1297637. eCollection 2023.
2
Anti-Melanogenic Effects of Fractioned by Regulation of cAMP/MITF Pathway in a UVB-Stimulated Mice Model.分段式 对 UVB 刺激的小鼠模型中 cAMP/MITF 通路的调控的抗黑色素生成作用。
Cells. 2023 May 14;12(10):1390. doi: 10.3390/cells12101390.
3
The Genus P. Browne as a Source of Biologically Active Phytochemicals for Pharmaceutical Application and Beyond-A Review.
综述：作为药物应用和超越药物应用的生物活性植物化学成分来源的 Browne 属植物。
Int J Mol Sci. 2023 Apr 1;24(7):6614. doi: 10.3390/ijms24076614.
4
Greene: Phytochemical Profile and Cosmeceutical and Dermatological Properties of Its Leaf Extracts.格林：其叶片提取物的植物化学成分谱、化妆品学和皮肤科特性。
Molecules. 2023 Jan 20;28(3):1036. doi: 10.3390/molecules28031036.
5
Natural products in cosmetics.化妆品中的天然产物。
Nat Prod Bioprospect. 2022 Nov 28;12(1):40. doi: 10.1007/s13659-022-00363-y.
6
Correction: Inhibitory effect of a genistein derivative on pigmentation of Guinea pig skin.更正：金雀异黄素衍生物对豚鼠皮肤色素沉着的抑制作用。
RSC Adv. 2018 Feb 13;8(13):7133. doi: 10.1039/c8ra90012d. eCollection 2018 Feb 9.
7
Synthesis and biological evaluation of 1,2,4-triazole derivatives as potential Nrf2 activators for the treatment of cerebral ischemic injury.1,2,4-三唑衍生物的合成及作为治疗脑缺血损伤的潜在 Nrf2 激活剂的生物评价。
Eur J Med Chem. 2022 Jun 5;236:114315. doi: 10.1016/j.ejmech.2022.114315. Epub 2022 Mar 28.
8
Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process.植物源抗氧化剂：在皮肤健康和衰老过程中的意义。
Int J Mol Sci. 2022 Jan 6;23(2):585. doi: 10.3390/ijms23020585.
9
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Int J Mol Sci. 2021 Oct 6;22(19):10799. doi: 10.3390/ijms221910799.
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Arbutin as a Skin Depigmenting Agent with Antimelanogenic and Antioxidant Properties.熊果苷作为一种具有抗黑素生成和抗氧化特性的皮肤美白剂。
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