真实世界病例系列：A.G.E. 中断者极致精华液
Real World Case Series: A.G.E. Interrupter Ultra Serum.
作者信息
Abdulla Sonya, Brieva Patricia, Cartier Hugues, Dierickx Christine, Guénin Sophie, Haus Ariel, van Loghem Jani, Shahbaz Ali, Schicher Nikolaus, Bjerring Peter
机构信息
Dermatology on Bloor, Toronto, Ontario, Canada.
SkinCeuticals, New York, New York, USA.
出版信息
J Cosmet Dermatol. 2025 Jul;24 Suppl 3(Suppl 3):e70302. doi: 10.1111/jocd.70302.
BACKGROUND
The A.G.E. Interrupter serum has been developed in an oil-in-water emulsion to contain 30% proxylane, Cassia alata extract, blueberry and pomegranate extract, rhamnose, and gentiana lutea root extract. The technology has several patent ingredients as well as synergistic patents with proxylane, rhamnose, and new ones submitted for the new ingredients. An ex vivo model using this final formulation has shown upregulation of laminin-5, collagen IV, tropoelastin, and collagen III. Collagen IV and laminin are present in the dermal-epidermal junction (DEJ) and are factors in the basement membrane function. Over time, the DEJ decreases in height and in surface area, leading to weakened skin integrity and structure. The serum was tested to illustrate visible life in the jawline, forehead, cheek, and neck as well as instrumental testing showing visible improvement in the nasolabial fold and forehead wrinkle.
AIM
To present a real-world case series that demonstrates the use of the A.G.E. Interrupter serum as an adjunctive therapy to collagen-stimulating procedures in a wide variety of patient ages and skin types.
METHODS
Eight internationally recognized, licensed dermatologists with extensive experience in cosmetic and facial rejuvenation procedures were selected to participate in an expert panel. During the expert panel, dermatologists were asked to share 2 cases using the A.G.E. Interrupter serum in patients undergoing collagen-stimulating procedures.
RESULTS
Following the panel discussion, seven patient cases were selected to illustrate the use of the A.G.E. Interrupter serum in conjunction with collagen-stimulating procedures to optimize patient outcomes and satisfaction. Experts found that daily A.G.E. Interrupter serum application post-procedure led to improved overall results and high patient satisfaction.
CONCLUSION
This case series provides evidence for different integrated skincare regimens using the A.G.E. Interrupter serum in a variety of patients.
背景
A.G.E. 中断者精华液采用水包油乳液配方，含有30%的原花青素、翅荚决明提取物、蓝莓和石榴提取物、鼠李糖以及黄龙胆根提取物。该技术拥有多种专利成分，以及与原花青素、鼠李糖相关的协同专利，还有针对新成分提交的专利。使用这种最终配方的体外模型已显示层粘连蛋白-5、IV型胶原蛋白、原弹性蛋白和III型胶原蛋白上调。IV型胶原蛋白和层粘连蛋白存在于真皮-表皮交界处（DEJ），是基底膜功能的因素。随着时间推移，DEJ的高度和表面积会减小，导致皮肤完整性和结构减弱。该精华液经过测试，在颌线、额头、脸颊和颈部展现出明显效果，仪器测试表明鼻唇沟和额头皱纹有明显改善。
目的
呈现一个真实案例系列，展示A.G.E. 中断者精华液作为辅助疗法，在各种年龄和皮肤类型的患者中与胶原蛋白刺激程序联合使用的情况。
方法
挑选了八位在美容和面部年轻化程序方面经验丰富、国际认可的持牌皮肤科医生参加专家小组。在专家小组会议期间，要求皮肤科医生分享2例在接受胶原蛋白刺激程序的患者中使用A.G.E. 中断者精华液的案例。
结果
经过小组讨论，选择了七个患者案例来说明A.G.E. 中断者精华液与胶原蛋白刺激程序联合使用，以优化患者治疗效果和满意度。专家们发现，术后每日使用A.G.E. 中断者精华液可改善整体效果并提高患者满意度。
结论
本案例系列为在各种患者中使用A.G.E. 中断者精华液的不同综合护肤方案提供了证据。
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