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癌症研究的发展历程。

The evolution of cancer research.

作者信息

Cairns J

机构信息

Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115.

出版信息

Cancer Cells. 1989 Sep;1(1):1-8.

PMID:2701356
Abstract

The modern War against Cancer began in the United States in 1970 with the publication of the Yarborough Report, which set forth recommendations and delineated the "means and measures necessary to facilitate success in the treatment, cure and elimination of cancer--at the earliest possible date." If the architects of the Report had known more about the history of the conquest of diseases, we might by now have made a greater impact on the death rate from cancer. As many people have pointed out, the exercise was not that of mobilizing a vast amount of money and resources in order to apply an existing technology to a very limited goal--some special bombs for one or two airplanes and the support for a few astronauts. Quite the opposite, the problem required the development of a level of understanding and a technological base which would allow solutions to the cancer problem that are so inexpensive that they can be offered to 200 million people.

摘要

现代抗癌战争于1970年在美国拉开帷幕,随着亚伯勒报告的发表,该报告提出了建议,并勾勒出“为尽早成功治疗、治愈和消除癌症所需的手段和措施”。如果该报告的起草者对疾病征服史了解得更多,我们现在可能会对癌症死亡率产生更大的影响。正如许多人所指出的,这项工作并非是为了将现有技术应用于非常有限的目标而筹集大量资金和资源——为一两架飞机配备一些特殊炸弹并支持少数宇航员。恰恰相反,这个问题需要发展一种理解水平和技术基础,以便找到成本如此低廉以至于能够提供给2亿人的癌症解决方案。

相似文献

1
The evolution of cancer research.癌症研究的发展历程。
Cancer Cells. 1989 Sep;1(1):1-8.
2
Beware the Medical-Industrial Complex.警惕医疗产业联合体。
Oncologist. 1996;1(4):IV-V.
3
The Cost of Biological Terrorism.生物恐怖主义的代价。
Oncologist. 1997;2(6):XI-XII.
4
The NCI All Ireland Cancer Conference.美国国家癌症研究所全爱尔兰癌症会议。
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[Scientific standards in parasitology in historical perspective].[寄生虫学历史视角下的科学标准]
Wiad Parazytol. 2005;51(3):197-207.
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Cancer registration: historical aspects.癌症登记:历史方面
IARC Sci Publ. 1985(66):3-12.
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Anticancer Drug Development: The Way Forward.抗癌药物研发:前进之路
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[Controlled randomized clinical trials].[对照随机临床试验]
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Prophylactic Oophorectomy: Reducing the U.S. Death Rate from Epithelial Ovarian Cancer. A Continuing Debate.预防性卵巢切除术:降低美国上皮性卵巢癌死亡率。一场持续的争论。
Oncologist. 1996;1(5):326-330.

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1
Recapitulating the Tumor Ecosystem Along the Metastatic Cascade Using 3D Culture Models.使用3D培养模型重现转移级联过程中的肿瘤生态系统。
Front Oncol. 2015 Jul 29;5:170. doi: 10.3389/fonc.2015.00170. eCollection 2015.
2
Expression of extracellular matrix proteins in cervical squamous cell carcinoma--a clinicopathological study.宫颈鳞状细胞癌中细胞外基质蛋白的表达——一项临床病理研究
J Clin Pathol. 1998 Oct;51(10):781-5. doi: 10.1136/jcp.51.10.781.
3
Adaptive mutations in Escherichia coli as a model for the multiple mutational origins of tumors.
大肠杆菌中的适应性突变作为肿瘤多突变起源的模型。
Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5669-73. doi: 10.1073/pnas.92.12.5669.
4
The second Bagshawe lecture. Matching basic research to the management of cancer: the view from the other side of the fence.第二届巴格肖讲座。基础研究与癌症治疗的匹配:旁观者的视角。
Br J Cancer. 1990 Sep;62(3):341-7. doi: 10.1038/bjc.1990.294.
5
Cancer as a mechanism of hypermutation.癌症作为一种超突变机制。
Acta Biotheor. 1992 Mar;40(1):31-40. doi: 10.1007/BF00046549.