Ruoslahti E, Giancotti F G
Cancer Research Center, La Jolla Cancer Research Foundation, California 92037.
Cancer Cells. 1989 Dec;1(4):119-26.
The ability of a tumor cell to metastasize is determined, in part, by its adhesive interactions with other cells and with components of the extracellular matrix. An ever-expanding family of cell surface receptors, the integrins, is an essential player in these interactions. Research efforts aimed at understanding the precise role of individual integrins in normal and transformed cells may offer a general framework for future therapeutic approaches. Here we review recent progress toward this goal.
肿瘤细胞的转移能力部分取决于其与其他细胞以及细胞外基质成分的黏附相互作用。整合素作为一个不断扩大的细胞表面受体家族，在这些相互作用中起着至关重要的作用。旨在了解单个整合素在正常细胞和转化细胞中的确切作用的研究工作，可能为未来的治疗方法提供一个总体框架。在此，我们综述了在这一目标上取得的最新进展。
