Huijskens Mirelle J A J, Wodzig Will K W H, Walczak Mateusz, Germeraad Wilfred T V, Bos Gerard M J
Department of Internal Medicine, Division of Hematology, Maastricht University Medical Center, Maastricht, The Netherlands.
Department of Clinical Chemistry, Maastricht University Medical Center, Maastricht, The Netherlands.
Results Immunol. 2016 Jan 12;6:8-10. doi: 10.1016/j.rinim.2016.01.001. eCollection 2016.
In this paper we demonstrate that patients treated with chemotherapy and/or hematopoietic stem cell transplantation (HSCT) have highly significant reduced serum ascorbic acid (AA) levels compared to healthy controls. We recently observed in in vitro experiments that growth of both T and NK cells from hematopoietic stem cells is positively influenced by AA. It might be of clinical relevance to study the function and recovery of immune cells after intensive treatment, its correlation to AA serum levels and the possible effect of AA supplementation.
在本文中，我们证明，与健康对照组相比，接受化疗和/或造血干细胞移植（HSCT）治疗的患者血清抗坏血酸（AA）水平显著降低。我们最近在体外实验中观察到，造血干细胞来源的T细胞和NK细胞的生长均受到AA的正向影响。研究强化治疗后免疫细胞的功能和恢复情况、其与血清AA水平的相关性以及补充AA的可能效果可能具有临床意义。
