Mk Nair Pradeep, Silwal Karishma, Ramalakshmi Renganathan, Devibala Muniappan, Saranya Maruthanayagam, Sivaranjani Sekar, Ramasamy Thangavelu, Palanisamy Ayyappan, Mahalingam Manickam
Department of Integrative Oncology, Mirakle Integrated Health Centre, Pollachi, India.
Department of Naturopathy, Sant Hirdaram Medical College of Naturopathy and Yogic Sciences, Bhopal, India.
Front Oncol. 2024 Sep 18;14:1455022. doi: 10.3389/fonc.2024.1455022. eCollection 2024.
Cancer is traditionally approached as a genetic disease, with standard treatments including chemotherapy, radiation, targeted therapy, immunotherapy, and surgery significantly improving survival rates and patient outcomes. However, there is a growing recognition of the need for integrative oncology, which expands cancer management by considering cancer as a metabolic disease. Integrative medicine physicians employ holistic therapies focused on patients' needs, aiming to correct the metabolic imbalances associated with cancer and alleviate cancer-related symptoms. Viewing cancer as a metabolic disease involves addressing factors such as an acidic microenvironment, vitamin C deficiency, mitochondrial dysfunction, reduced intracellular oxygen levels, elevated oxidative stress, dysfunctional autophagy, and psychological stress. This paper presents an overview of the evidence and comprehensive strategies supporting integrative medicine approaches in addressing cancer metabolism in integrative oncology settings. Furthermore, the paper underscores the necessity of integrating different cancer theories-genetic and metabolic-for improved patient outcomes and experiences. By combining these perspectives, integrative oncology offers a more holistic, patient-centered approach to cancer treatment.
传统上，癌症被视为一种基因疾病，标准治疗方法包括化疗、放疗、靶向治疗、免疫治疗和手术，这些方法显著提高了生存率和患者预后。然而，人们越来越认识到综合肿瘤学的必要性，即通过将癌症视为一种代谢疾病来扩展癌症管理。综合医学医生采用以患者需求为重点的整体疗法，旨在纠正与癌症相关的代谢失衡并缓解癌症相关症状。将癌症视为代谢疾病涉及解决诸如酸性微环境、维生素C缺乏、线粒体功能障碍、细胞内氧水平降低、氧化应激升高、自噬功能失调和心理压力等因素。本文概述了支持综合医学方法在综合肿瘤学环境中解决癌症代谢问题的证据和综合策略。此外，本文强调了整合不同癌症理论（基因和代谢）以改善患者预后和体验的必要性。通过结合这些观点，综合肿瘤学为癌症治疗提供了一种更全面、以患者为中心的方法。
