Desowitz R S, Shida K K, Pang L, Buchbinder G
John A. Burns School of Medicine, University of Hawaii, Honolulu.
Am J Trop Med Hyg. 1989 Dec;41(6):630-4. doi: 10.4269/ajtmh.1989.41.630.
This study characterizes a Plasmodium berghei white rat model of P. falciparum malaria in the pregnant human. Seventy-day-old and 114-day-old female rats, given an infecting inoculum at time of mating, had higher parasitemias and a more severe anemia than age- and sex-matched controls. Under these experimental conditions, the parasitemia went to crisis in all animals and there were no fatal infections. In contrast, all animals died when the infection was initiated 7 days after conception, a timing that brought a coincidence of peak parasitemia and term. Pregnancy during the post-crisis subpatent period did not cause recrudescence. At the time of delivery, the parasitemia was consistently higher in the placental (crush smear) blood than in the peripheral (tail) blood. This difference was greatest in animals giving birth shortly before or 1-2 days after the parasitemic crisis. Very young, compact parasite forms predominated in the placental blood, whereas trophozoites predominated in the peripheral blood.
本研究描述了一种用于模拟人类孕妇恶性疟原虫疟疾的伯氏疟原虫白鼠模型。70日龄和114日龄的雌性大鼠在交配时接种感染接种物，与年龄和性别匹配的对照组相比，其寄生虫血症更高，贫血更严重。在这些实验条件下，所有动物的寄生虫血症均进入危机期，且无致命感染。相比之下，当在受孕后7天开始感染时，所有动物均死亡，这一时期寄生虫血症峰值与足月同时出现。危机后亚临床期妊娠并未导致复发。分娩时，胎盘（压片涂片）血中的寄生虫血症始终高于外周（尾部）血。这种差异在寄生虫血症危机前或危机后1 - 2天分娩的动物中最为明显。胎盘血中以非常小的、紧密的寄生虫形态为主，而外周血中则以滋养体为主。
