Zhao Lihong, Li Xiaoying, Ji Cheng, Rong Xiaoping, Liu Shujing, Zhang Jianyun, Ma Qiugang
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, No. 2. West Road Yuanming yuan, Beijing 100193, PR China.
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, No. 2. West Road Yuanming yuan, Beijing 100193, PR China.
Food Chem Toxicol. 2016 Jun;92:143-9. doi: 10.1016/j.fct.2016.03.020. Epub 2016 Mar 23.
This study was conducted to investigate the toxic effects of deoxynivalenol (DON) and the ameliorating efficacy of Devosia sp. ANSB714 for the negative effects of DON on mice. In the experiment, 80 mice were randomly divided into 4 treatments: non-toxin control, toxin, non-toxin control + ANSB714 and toxin + ANSB714. During 28 days, the mice in treatment with 4.70 mg/kg DON only had significantly lower average daily gain as compared those with non-toxin control treatment (P < 0.05). Serum blood urea nitrogen, tumour necrosis factor-α and the residues of DON in kidneys in mice received the toxin diet were obviously higher than those with non-toxin control (P < 0.05). There were no significant differences (P > 0.05) between ANSB714 treatments and non-ANSB714 treatments on above parameters of mice. Adding ANSB714 to toxic diets could normalize deviant physiological effects of DON on mice.
本研究旨在探讨脱氧雪腐镰刀菌烯醇（DON）的毒性作用以及德沃斯氏菌属ANSB714对DON对小鼠负面影响的改善效果。实验中，80只小鼠被随机分为4组：无毒对照组、毒素组、无毒对照组+ANSB714组和毒素+ANSB714组。在28天的实验期间，仅接受4.70 mg/kg DON处理的小鼠的平均日增重显著低于无毒对照组（P<0.05）。接受毒素饮食的小鼠血清中的血尿素氮、肿瘤坏死因子-α以及肾脏中DON的残留量明显高于无毒对照组（P<0.05）。在上述小鼠参数方面，ANSB714处理组和非ANSB714处理组之间无显著差异（P>0.05）。在有毒饮食中添加ANSB714可以使DON对小鼠的异常生理影响恢复正常。
