State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, PR China; Animal Nutrition and Feed Center, COFCO Nutrition and Health Research Institute, Beijing, 102209, PR China.
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, PR China.
Food Chem Toxicol. 2018 Nov;121:246-251. doi: 10.1016/j.fct.2018.09.007. Epub 2018 Sep 8.
This study aimed to investigate the toxic effects of deoxynivalenol (DON) and the effectiveness of Devosia sp. ANSB714 for alleviation of DON toxicosis in growing-finishing pigs. A total of twenty pigs were allocated equally to four treatments for 18 days: CON (basal diet formulated with normal rice), Devosia sp. ANSB714 (CON + Devosia sp. ANSB714), DON (toxic diet formulated with DON-contaminated rice), and DON + Devosia sp. ANSB714. The treatments of Devosia sp. ANSB714 and DON + Devosia sp. ANSB714 were given the fermentation liquor of Devosia sp ANSB714 by drinking water. DON-contaminated diet significantly decreased the average daily gain of growing-finishing pigs. Serum IgA content was significantly increased in DON treatment compared with that in CON. Besides, DON in diet also significantly reduced the activities of GSH-Px in the liver and serum of pigs. Supplementation of Devosia sp. ANSB714 in drinking water effectively prevented these adverse effects of DON on pigs. Moreover, the DON residues in the serum, liver and kidney were significantly decreased with the addition of Devosia sp. ANSB714 to diet contaminated with DON. Taken together, it is effective to feeding Devosia sp. ANSB714 to pigs fed with diet contaminated with DON and ameliorating DON toxicosis of pigs.
本研究旨在探讨脱氧雪腐镰刀菌烯醇（DON）的毒性作用，以及 Devosia sp. ANSB714 对生长育肥猪 DON 中毒的缓解效果。共 20 头猪被平均分配到 4 个处理组中，每个处理组持续 18 天：CON（用正常大米配制的基础日粮）、Devosia sp. ANSB714（CON+Devosia sp. ANSB714）、DON（用受 DON 污染的大米配制的有毒日粮）和 DON+Devosia sp. ANSB714。Devosia sp. ANSB714 和 DON+Devosia sp. ANSB714 的处理组通过饮用水给予 Devosia sp. ANSB714 的发酵液。受 DON 污染的日粮显著降低了生长育肥猪的平均日增重。与 CON 相比，DON 处理组血清 IgA 含量显著增加。此外，日粮中的 DON 还显著降低了猪肝脏和血清中 GSH-Px 的活性。在饮水中补充 Devosia sp. ANSB714 有效地防止了 DON 对猪的这些不良影响。此外，在受 DON 污染的日粮中添加 Devosia sp. ANSB714 可显著降低血清、肝脏和肾脏中的 DON 残留量。综上所述，给饲喂受 DON 污染日粮的猪饲喂 Devosia sp. ANSB714 是有效的，可缓解猪的 DON 中毒。
