老年人维生素 D 状况与代谢综合征：鹿特丹研究。

Vitamin D status and metabolic syndrome in the elderly: the Rotterdam Study.

机构信息

Departments of Epidemiology, Internal Medicine, Erasmus MCUniversity Medical Center, Rotterdam, The Netherlands.

Departments of Epidemiology, Internal Medicine, Erasmus MCUniversity Medical Center, Rotterdam, The Netherlands

出版信息

Eur J Endocrinol. 2015 Mar;172(3):327-35. doi: 10.1530/EJE-14-0580. Epub 2014 Dec 2.

DOI:10.1530/EJE-14-0580

PMID:25468955

Abstract

OBJECTIVE

The effects of vitamin D in the elderly are inconsistent. The aim of this study was to evaluate the association between vitamin D status and the metabolic syndrome (MetS) in the elderly, as well as between vitamin D status and the components of MetS (i.e. serum glucose, triglycerides (TG), HDL cholesterol (HDL-C), waist circumference (WC), and blood pressure (BP)).

METHODS

The study was embedded in the Rotterdam Study, a population-based cohort of middle-aged and elderly adults. We analyzed data from 3240 people (median age 71.2 years) who did not have type 2 diabetes mellitus at baseline.

RESULTS

We found higher 25-hydroxyvitamin D (25(OH)D) concentrations associated with lower prevalence of MetS (odds ratio (OR); 95% CI: 0.61; 0.49, 0.77 for adequate levels (≥75 nmol/l) vs deficiency (<50 nmol/l). In addition, in analysis of the individual components, the ORs for adequate vs deficient vitamin D levels were: 0.66 (95% CI 0.53, 0.83) for elevated WC, 0.67 (95% CI 0.52, 0.86) for reduced HDL-C, 0.69 (95% CI 0.54, 0.88) for elevated TG, and 0.80 (95% CI 0.65, 0.99) for elevated fasting glucose. Vitamin D was not associated with elevated blood pressure, and ORs for adequacy vs deficiency were 0.82 (95% CI 0.65, 1.03).

CONCLUSION

Higher 25(OH)D concentrations in the elderly are associated with lower prevalence of MetS and, in particular, with more beneficial HDL-C, TG, WC, and serum glucose. Since the prevalence of vitamin D deficiency is common worldwide and its risk increases with age, if causality is proven, benefits of improving vitamin D status among the elderly may be great.

摘要

目的

老年人维生素 D 的作用并不一致。本研究旨在评估老年人维生素 D 状况与代谢综合征（MetS）之间的关系，以及维生素 D 状况与 MetS 各组成部分（即血清葡萄糖、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、腰围（WC）和血压（BP））之间的关系。

方法

本研究嵌入了鹿特丹研究，这是一项针对中老年人群的基于人群的队列研究。我们分析了基线时没有 2 型糖尿病的 3240 人的数据（中位年龄 71.2 岁）。

结果

我们发现较高的 25-羟维生素 D（25（OH）D）浓度与较低的 MetS 患病率相关（比值比（OR）；95%可信区间：0.61；0.49，0.77，对于充足水平（≥75nmol/L）与缺乏（<50nmol/L）相比）。此外，在对各个成分的分析中，充足的维生素 D 水平与缺乏的维生素 D 水平的比值比为：WC 升高时为 0.66（95%可信区间 0.53，0.83），HDL-C 降低时为 0.67（95%可信区间 0.52，0.86），TG 升高时为 0.69（95%可信区间 0.54，0.88），空腹血糖升高时为 0.80（95%可信区间 0.65，0.99）。维生素 D 与血压升高无关，充足与缺乏的比值比为 0.82（95%可信区间 0.65，1.03）。