Niwa Yukiko, Koike Masahiko, Hattori Masashi, Iwata Naoki, Takami Hideki, Hayashi Masamichi, Kanda Mitsuro, Kobayashi Daisuke, Tanaka Chie, Yamada Suguru, Fujii Tsutomu, Nakayama Goro, Sugimoto Hiroyuki, Nomoto Shuji, Fujiwara Michitaka, Kodera Yasuhiro
Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan.
Nagoya J Med Sci. 2016 Feb;78(1):69-78.
In our department, we have attempted to reduce the incidence of complications of conventional esophagectomy. The objective of this retrospective study was to report the short-term outcomes of esophagectomy. We reviewed 138 consecutive patients who had undergone subtotal esophagectomy by combined laparotomy via a 12-cm upper abdominal vertical incision combined with right anterior muscle-sparing thoracotomy from August 2010 to August 2014. Most of the cervical para-esophageal lymph node dissection was completed within the thoracic cavity. We performed three-field dissection in patients with tumors in the upper or middle third of the esophagus with clinical lymph node metastases in the superior mediastinum; the others underwent two-field dissection. We performed neck anastomoses in patients undergoing three-field dissection and thoracic anastomoses in those undergoing two-field dissection. Effective postoperative pain management was achieved with a combination of epidural anesthesia and paravertebral block. Postoperative rehabilitation was instituted for early ambulation and recovery. Enteral nutrition via a duodenal feeding tube was administered from postoperative day 2. Median hospital stay after surgery was 15 days (range, 10-129). Rates for both 30-day and in-hospital mortality were 0%. Morbidity rate for all Clavien-Dindo grades was 41.3%, whereas the morbidity rate for Clavien-Dindo grades III and IV was 7.2%. Anastomotic leakage developed in two patients (1.4%), recurrent laryngeal nerve palsy in 11 (8.0%), and pneumonia in nine (6.5%). Good short-term outcomes, especially regarding anastomotic leaks, were achieved by consistent improvements in surgical techniques, optimization of several operative procedures, and appropriate perioperative management.
在我们科室,我们一直致力于降低传统食管癌切除术并发症的发生率。这项回顾性研究的目的是报告食管癌切除术的短期结果。我们回顾了2010年8月至2014年8月期间连续138例行次全食管切除术的患者,手术方式为经12厘米上腹部垂直切口联合右前侧保留肌肉开胸术的剖腹联合手术。大部分颈段食管旁淋巴结清扫在胸腔内完成。对于食管上三分之一或中三分之一且临床上纵隔淋巴结转移的肿瘤患者,我们进行了三野清扫;其他患者则进行了两野清扫。接受三野清扫的患者进行颈部吻合,接受两野清扫的患者进行胸内吻合。通过硬膜外麻醉和椎旁阻滞相结合实现了有效的术后疼痛管理。术后开始康复治疗以促进早期活动和恢复。术后第2天开始经十二指肠喂养管进行肠内营养。术后中位住院时间为15天(范围10 - 129天)。30天和住院死亡率均为0%。所有Clavien-Dindo分级的发病率为41.3%,而Clavien-Dindo III级和IV级的发病率为7.2%。两名患者(1.4%)发生吻合口漏,11名患者(8.0%)发生喉返神经麻痹,9名患者(6.5%)发生肺炎。通过持续改进手术技术、优化多项手术操作以及适当的围手术期管理,取得了良好的短期结果,尤其是在吻合口漏方面。