Department of Thyroid Gland and Breast Surgery, Guidong People's Hospital of Guangxi Zhuang Autonomous Region, Wuzhou 543001, Guangxi, China.
Department of Medical Management, Guidong People's Hospital of Guangxi Zhuang Autonomous Region, Wuzhou 543001, Guangxi, China.
J Healthc Eng. 2022 Mar 8;2022:3642799. doi: 10.1155/2022/3642799. eCollection 2022.
Fibroadenoma of the breast is a common cause of a benign breast lump in premenopausal women. The consensus view is that women with fibroadenomas are not at significantly increased risk of developing breast cancer. The objective of this research was to explore the association of PON1 rs662 and rs705382 with the risk of breast fibroadenoma (BF) and breast cancer (BC) in the females of Guangxi in southern China. The PON1 rs662 and rs705382 single-nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 55 BF patients, 80 BC patients, and 98 healthy controls. Significant associations with FB and BC risks were observed for the rs662 SNP. Diagnosis is based on the combination of clinical examination, imaging, and nonsurgical tissue biopsy (the triple test) [21]. In haplotype analyses, the haplotype GA increases the risk and haploid GG decreases the risk in BF and BC. Our research indicated that the PON1 rs662 SNP might be a risk factor for BF and BC. The results of this research indicated that the locus of rs662 in PON1 is relevant to risk of developing BF and BC in the females of Guangxi. Further prospective studies are needed to support our conclusions.
乳腺纤维腺瘤是育龄期妇女常见的良性乳腺肿块。目前的共识认为，患有乳腺纤维腺瘤的女性发生乳腺癌的风险没有显著增加。本研究旨在探讨广西女性载脂蛋白 PON1 rs662 和 rs705382 单核苷酸多态性与乳腺纤维腺瘤（BF）和乳腺癌（BC）风险的相关性。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法对 55 例 BF 患者、80 例 BC 患者和 98 例健康对照者的 PON1 rs662 和 rs705382 单核苷酸多态性（SNP）进行基因分型。rs662 单核苷酸多态性与 BF 和 BC 风险显著相关。诊断基于临床检查、影像学和非手术组织活检（三联试验）[21]。在单倍型分析中，GA 单倍型增加 BF 和 BC 的风险，GG 单倍型降低 BF 和 BC 的风险。本研究表明，PON1 rs662 单核苷酸多态性可能是 BF 和 BC 的危险因素。本研究结果表明，PON1 基因座 rs662 与广西女性发生 BF 和 BC 的风险有关。需要进一步的前瞻性研究来支持我们的结论。
