Lupo Philip J, Robinson Jill O, Diamond Pamela M, Jamal Leila, Danysh Heather E, Blumenthal-Barby Jennifer, Lehmann Lisa Soleymani, Vassy Jason L, Christensen Kurt D, Green Robert C, McGuire Amy L
Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
Center for Medical Ethics & Health Policy, Baylor College of Medicine, Houston, TX 77030, USA.
Per Med. 2016 Jan 1;13(1):13-20. doi: 10.2217/pme.15.45. Epub 2016 Jan 8.
To evaluate patients' expectations regarding the perceived utility of whole-genome sequencing (WGS).
MATERIALS & METHODS: We used latent class analysis to characterize individuals enrolled in the MedSeq Project based on their perceived utility of WGS. Multinomial logistic regression was used to evaluate associations between participant characteristics and latent classes.
Findings characterized participants into one of three perceived utility groups: enthusiasts, who had a high probability of agreement with all utility items (23%); health conscious, who perceived utility in medically related areas (60%) or skeptics, who had a low probability of agreement with utility items (17%). Trust significantly predicted latent class.
Understanding differences in perceived utility of WGS may inform strategies for uptake of this technology.
评估患者对全基因组测序（WGS）感知效用的期望。
我们使用潜在类别分析，根据全基因组测序的感知效用对参与MedSeq项目的个体进行特征描述。多项逻辑回归用于评估参与者特征与潜在类别之间的关联。
研究结果将参与者分为三个感知效用组之一：热心者，他们对所有效用项目高度认同的可能性很高（23%）；健康意识者，他们在医学相关领域感知到效用（60%）；或怀疑者，他们对效用项目认同的可能性很低（17%）。信任显著预测潜在类别。
了解全基因组测序感知效用的差异可能为该技术的应用策略提供信息。
