Papadopoulos Vassilis, Tsapakidis Konstantinos, Riobo Del Galdo Natalia A, Papandreou Christos N, Del Galdo Francesco, Anthoney Alan, Sakellaridis Nikos, Dimas Konstantinos, Kamposioras Konstantinos
Department of Medical Oncology, University Hospital of Larissa, Larissa, Greece.
Department of Biochemistry and Molecular Biology and Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA.
Clin Colorectal Cancer. 2016 Jun;15(2):116-27. doi: 10.1016/j.clcc.2016.02.010. Epub 2016 Feb 16.
Despite significant advances in the management of colorectal cancer (CRC) the identification of new prognostic biomarkers continues to be a challenge. Since its initial discovery, the role of the Hedgehog (Hh) signaling pathway in carcinogenesis has been extensively studied. We herein review and comment on the prognostic significance of the Hh signaling pathway in CRC. The differential expression of Hh pathway components between malignant and nonmalignant conditions as well as correlation of Hh activation markers with various clinicopathological parameters and the effect on disease-free survival, overall survival, and disease recurrence in patients with CRC is summarized and discussed. According to the studies reviewed herein the activation of the Hh pathway seems to be correlated with adverse clinicopathological features and worse survival. However, to date study results show significant variability with regard to the effect on outcomes. Such results need to be interpreted carefully and emphasize the need for further well designed studies to characterize the actual influence of the Hh pathway in CRC prognosis.
尽管在结直肠癌（CRC）的管理方面取得了重大进展，但鉴定新的预后生物标志物仍然是一项挑战。自最初发现以来，刺猬（Hh）信号通路在致癌作用中的作用已得到广泛研究。我们在此综述并评论Hh信号通路在CRC中的预后意义。总结并讨论了恶性和非恶性条件下Hh通路成分的差异表达，以及Hh激活标志物与各种临床病理参数的相关性，以及对CRC患者无病生存期、总生存期和疾病复发的影响。根据本文综述的研究，Hh通路的激活似乎与不良临床病理特征和较差的生存率相关。然而，迄今为止的研究结果在对预后的影响方面显示出显著的变异性。这些结果需要仔细解读，并强调需要进一步设计良好的研究来确定Hh通路在CRC预后中的实际影响。
