Fan Boyang, Zhang Qian, Wang Ning, Wang Guiyu
Department of Colorectal Cancer Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Department of Colorectal Surgery, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China.
Front Oncol. 2022 Jan 27;12:811374. doi: 10.3389/fonc.2022.811374. eCollection 2022.
Colorectal cancer stem cells (CRCSCs) can actively self-renew, as well as having multidirectional differentiation and tumor regeneration abilities. Because the high functional activities of CRCSCs are associated with low cure rates in patients with colorectal cancer, efforts have sought to determine the function and regulatory mechanisms of CRCSCs. To date, however, the potential regulatory mechanisms of CRCSCs remain incompletely understood. Many non-coding genes are involved in tumor invasion and spread through their regulation of CRCSCs, with long non-coding RNAs (lncRNAs) being important non-coding RNAs. LncRNAs may be involved in the colorectal cancer development and drug resistance through their regulation of CRCSCs. This review systematically evaluates the latest research on the ability of lncRNAs to regulate CRCSC signaling pathways and the involvement of these lncRNAs in colorectal cancer promotion and suppression. The regulatory network of lncRNAs in the CRCSC signaling pathway has been determined. Further analysis of the potential clinical applications of lncRNAs as novel clinical diagnostic and prognostic biomarkers and therapeutic targets for colorectal cancer may provide new ideas and protocols for the prevention and treatment of colorectal cancer.
结直肠癌干细胞（CRCSCs）能够积极地自我更新，同时具有多向分化和肿瘤再生能力。由于CRCSCs的高功能活性与结直肠癌患者的低治愈率相关，人们一直在努力确定CRCSCs的功能和调控机制。然而，迄今为止，CRCSCs的潜在调控机制仍未完全明确。许多非编码基因通过对CRCSCs的调控参与肿瘤的侵袭和扩散，长链非编码RNA（lncRNAs）是重要的非编码RNA。lncRNAs可能通过对CRCSCs的调控参与结直肠癌的发生发展和耐药性。本文系统评价了lncRNAs调控CRCSC信号通路能力的最新研究以及这些lncRNAs在促进和抑制结直肠癌中的作用。已确定lncRNAs在CRCSC信号通路中的调控网络。进一步分析lncRNAs作为结直肠癌新型临床诊断和预后生物标志物及治疗靶点的潜在临床应用，可能为结直肠癌的预防和治疗提供新思路和方案。
