Cao Feng, Chen Yang-Yan, Wang Hong-Cheng
Department of Care Section, Beijing Geriatric Hospital, Beijing 100095, China.
Research Department, Shanghai Zhangjiang Institute of Medical Innovation, Shanghai 200000, China.
World J Gastrointest Surg. 2024 May 27;16(5):1328-1335. doi: 10.4240/wjgs.v16.i5.1328.
Few studies have investigated the expression of and in patients undergoing radical surgery for colorectal carcinoma (CRC) and their association with lymph node metastasis (LNM). Therefore, more relevant studies and analyses need to be conducted.
To explore and expression in patients undergoing radical surgery for CRC and their correlation with LNM.
This study selected 103 patients with CRC admitted to our hospital between April 2020 and April 2023. Sample specimens of CRC and adjacent tissues were collected to determine the positive rates and expression levels of and . The correlation of the two genes with patients' clinicopathological data ( LNM) was explored, and differences in and expression between patients with LNM and those without were analyzed. Receiver operating characteristic (ROC) curves were plotted to evaluate the predictive potential of the two genes for LNM in patients with CRC.
Significantly higher positive rates and expression levels of and were observed in CRC tissue samples compared with adjacent tissues. and were strongly linked to LNM in patients undergoing radical surgery for CRC, with higher and levels found in patients with LNM than in those without. The areas under the ROC curve of and in assessing LNM in patients with CRC were 0.824 and 0.811, respectively.
and expression was upregulated in patients undergoing radical surgery for CRC and are significantly related to LNM in these patients. Moreover, high and expression can indicate LNM in patients with CRC undergoing radical surgery. The expression of both genes has certain diagnostic and therapeutic significance.
很少有研究调查结直肠癌（CRC）根治性手术患者中[具体基因名称未给出]和[具体基因名称未给出]的表达情况及其与淋巴结转移（LNM）的关联。因此，需要进行更多相关研究和分析。
探讨CRC根治性手术患者中[具体基因名称未给出]和[具体基因名称未给出]的表达及其与LNM的相关性。
本研究选取了2020年4月至2023年4月期间我院收治的103例CRC患者。收集CRC及癌旁组织样本，以确定[具体基因名称未给出]和[具体基因名称未给出]的阳性率和表达水平。探讨这两个基因与患者临床病理数据（LNM）的相关性，并分析有LNM和无LNM患者之间[具体基因名称未给出]和[具体基因名称未给出]表达的差异。绘制受试者工作特征（ROC）曲线，以评估这两个基因对CRC患者LNM的预测潜力。
与癌旁组织相比，CRC组织样本中[具体基因名称未给出]和[具体基因名称未给出]的阳性率和表达水平显著更高。在接受CRC根治性手术的患者中，[具体基因名称未给出]和[具体基因名称未给出]与LNM密切相关，有LNM的患者中[具体基因名称未给出]和[具体基因名称未给出]水平高于无LNM的患者。[具体基因名称未给出]和[具体基因名称未给出]在评估CRC患者LNM时的ROC曲线下面积分别为0.824和0.811。
在接受CRC根治性手术的患者中，[具体基因名称未给出]和[具体基因名称未给出]的表达上调，且与这些患者的LNM显著相关。此外，[具体基因名称未给出]和[具体基因名称未给出]的高表达可提示接受根治性手术的CRC患者存在LNM。这两个基因的表达具有一定的诊断和治疗意义。
