亲环素A：病毒复制的关键因素及抗病毒治疗的潜在靶点。
Cyclophilin A: A Key Factor in Virus Replication and Potential Target for Anti-viral Therapy.
作者信息
Dawar Farman Ullah, Tu Jiagang, Khattak Muhammad Nasir Khan, Mei Jie, Lin Li
机构信息
Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan, Hubei, 430070, China.
出版信息
Curr Issues Mol Biol. 2017;21:1-20. doi: 10.21775/cimb.021.001. Epub 2016 Mar 31.
Cyclophilin A (CypA) is a key member of immunophilins that has peptidyl-prolyl cis/trans isomerase (PPIase) activity. Besides acting as a cellular receptor for immunosuppressive drug cyclosporine A (CsA), CypA is involved in various cellular activities. CypA has an important role in viral infection which either facilitates or inhibits their replication. Inhibition of CypA via inhibitors is useful for overcoming several viral infections, indicating that CypA is an attractive target for anti-viral therapy. Collectively, these facts demonstrate the critical roles of CypA in mediating or inhibiting viral infections, suggesting that CypA can be an attractive cellular target for the development of anti-viral therapy.
亲环素A（CypA）是免疫亲和素的关键成员，具有肽基脯氨酰顺反异构酶（PPIase）活性。除了作为免疫抑制药物环孢素A（CsA）的细胞受体外，CypA还参与多种细胞活动。CypA在病毒感染中起着重要作用，它既可以促进也可以抑制病毒复制。通过抑制剂抑制CypA有助于克服多种病毒感染，这表明CypA是抗病毒治疗的一个有吸引力的靶点。总的来说，这些事实证明了CypA在介导或抑制病毒感染中的关键作用，表明CypA可能是抗病毒治疗开发中一个有吸引力的细胞靶点。
Zotero 插件