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中山眼科中心-布莱恩·霍尔登视力研究所高度近视登记研究中的视野缺损分类

Visual field defect classification in the Zhongshan Ophthalmic Center-Brien Holden Vision Institute High Myopia Registry Study.

作者信息

Ding Xiaohu, Chang Robert T, Guo Xinxing, Liu Xing, Johnson Chris A, Holden Brien A, He Mingguang

机构信息

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Department of Ophthalmology, Byers Eye Institute at Stanford University, Palo Alto, California, USA.

出版信息

Br J Ophthalmol. 2016 Dec;100(12):1697-1702. doi: 10.1136/bjophthalmol-2015-307942. Epub 2016 Mar 31.

Abstract

PURPOSE

To describe a new combined myopia and glaucoma visual field classification system in order to report the visual field defects in a population of mostly young Chinese high myopes aged 7-70 years.

METHODS

A total of 1434 visual fields (including confirmatory repeats of abnormal defects) from 487 high myopes (sphere ≤-6.0 D) were analysed from the prospective Zhongshan Ophthalmic Center-Brien Holden Vision Institute (ZOC-BHVI) High Myopia Registry Study. The predefined classification definitions covering high myopia and glaucoma categories were: normal, enlarged blind spot, abnormal suspect and abnormal with nine subtypes. Two independent graders reviewed the first 150 of 1434 fields for initial grading calibration and the remaining 1284 fields were used to assess intergrader agreement. For the percentage distribution of visual fields, the repeats and unreliable fields were excluded, leaving 894 fields.

RESULTS

The intergrader agreement of this combined classification system was a κ value of 0.61 (95% CI 0.59 to 0.63). Among the 894 unique fields, the most common visual field was normal at 33.7% followed by enlarged blind spot at 25.6%. The per cent of 'arcuate-like' field defects (combining nasal step, early arcuate and advanced arcuate) was 16.1% with advanced arcuate at 3.4%.

CONCLUSIONS

A proposed combined visual field classification for high myopia and glaucoma demonstrates acceptable intergrader agreement. A total of 16.1% of defects in young high myopes were found to mimic classic glaucomatous defects. These subjects are being followed prospectively to assess which ones will progress to differentiate myopic from glaucomatous field defects.

摘要

目的

描述一种新的近视合并青光眼视野分类系统,以便报告一组年龄在7至70岁的中国年轻高度近视人群的视野缺损情况。

方法

对来自中山眼科中心-布莱恩·霍尔登视力研究所(ZOC-BHVI)高度近视前瞻性登记研究中的487例高度近视患者(球镜度数≤-6.0 D)的1434份视野检查结果(包括异常缺损的确认性重复检查)进行分析。涵盖高度近视和青光眼类别的预定义分类定义为:正常、盲点扩大、异常可疑以及异常(含九个亚型)。两名独立的分级人员对1434份视野检查结果中的前150份进行初始分级校准,其余1284份视野检查结果用于评估分级人员间的一致性。对于视野检查结果的百分比分布,排除重复和不可靠的视野,共留下894份视野检查结果。

结果

该联合分类系统分级人员间的一致性κ值为0.61(95%可信区间0.59至0.63)。在894份独特的视野检查结果中,最常见的视野类型为正常,占33.7%,其次是盲点扩大,占25.6%。“弓形样”视野缺损(包括鼻侧阶梯、早期弓形和晚期弓形)的比例为16.1%,其中晚期弓形占3.4%。

结论

一种针对高度近视和青光眼的联合视野分类方法显示出可接受的分级人员间一致性。在年轻高度近视患者中,共发现16.1%的缺损类似于典型的青光眼性缺损。目前正在对这些受试者进行前瞻性随访观察,以评估哪些人会进展为近视性或青光眼性视野缺损。

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