阿尔茨海默病概述以及几种使用合成化合物和草药化合物靶向β淀粉样蛋白的治疗方法
Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds.
作者信息
Singh Sandeep Kumar, Srivastav Saurabh, Yadav Amarish Kumar, Srikrishna Saripella, Perry George
机构信息
Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India.
Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA.
出版信息
Oxid Med Cell Longev. 2016;2016:7361613. doi: 10.1155/2016/7361613. Epub 2015 Dec 28.
Alzheimer's disease (AD) is a complex age-related neurodegenerative disease. In this review, we carefully detail amyloid-β metabolism and its role in AD. We also consider the various genetic animal models used to evaluate therapeutics. Finally, we consider the role of synthetic and plant-based compounds in therapeutics.
阿尔茨海默病（AD）是一种复杂的与年龄相关的神经退行性疾病。在本综述中，我们详细阐述了β-淀粉样蛋白的代谢及其在AD中的作用。我们还考虑了用于评估治疗方法的各种基因动物模型。最后，我们探讨了合成化合物和植物性化合物在治疗中的作用。
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