Division of Molecular Biotechnology, Department of Physics, Chemistry and Biology, Linköping University, 58183 Linköping, Sweden.
Department of Neurobiology, Care Sciences and Society, Karolinska Institute, 17164 Solna, Sweden.
Int J Mol Sci. 2021 Sep 28;22(19):10448. doi: 10.3390/ijms221910448.
Alzheimer's disease is a widespread and devastating neurological disorder associated with proteotoxic events caused by the misfolding and aggregation of the amyloid-β peptide. To find therapeutic strategies to combat this disease, has proved to be an excellent model organism that is able to uncover anti-proteotoxic candidates due to its outstanding genetic toolbox and resemblance to human disease genes. In this review, we highlight the use of to both study the proteotoxicity of the amyloid-β peptide and to screen for drug candidates. Expanding the knowledge of how the etiology of Alzheimer's disease is related to proteotoxicity and how drugs can be used to block disease progression will hopefully shed further light on the field in the search for disease-modifying treatments.
阿尔茨海默病是一种广泛而严重的神经退行性疾病，与淀粉样β肽的错误折叠和聚集引起的蛋白毒性事件有关。为了寻找对抗这种疾病的治疗策略， 已被证明是一个优秀的模式生物，由于其出色的遗传工具包和与人类疾病基因的相似性，能够发现抗蛋白毒性候选物。在这篇综述中，我们强调了 使用 来研究淀粉样β肽的蛋白毒性并筛选药物候选物。扩展对阿尔茨海默病的病因与蛋白毒性的关系以及药物如何用于阻止疾病进展的了解，有望为寻找疾病修饰治疗方法的领域提供更多的启示。
