在整个孕期，血清饱和脂肪酸会降低血浆脂联素水平，并增加瘦素水平，且这一作用独立于体重指数（BMI）。

Serum saturated fatty acid decreases plasma adiponectin and increases leptin throughout pregnancy independently of BMI.

作者信息

Lepsch Jaqueline, Farias Dayana Rodrigues, Vaz Juliana Dos Santos, de Jesus Pereira Pinto Thatiana, da Silva Lima Natália, Freitas Vilela Ana Amélia, Cunha Marcelo, Factor-Litvak Pam, Kac Gilberto

机构信息

Nutritional Epidemiology Observatory, Josué de Castro Nutrition Institute, Rio de Janeiro Federal University, Rio de Janeiro, Brazil.

Faculty of Nutrition, Federal University of Pelotas, Pelotas, Brazil.

出版信息

Nutrition. 2016 Jul-Aug;32(7-8):740-7. doi: 10.1016/j.nut.2016.01.016. Epub 2016 Jan 30.

DOI:10.1016/j.nut.2016.01.016

PMID:27036610

Abstract

OBJECTIVE

The aim of this study was to investigate whether serum concentrations of total saturated fatty acids (SFAs), polyunsaturated fatty acids (PUFAs), and their fractions are associated with plasma adiponectin and leptin concentrations throughout pregnancy.

METHODS

A prospective cohort of 201 pregnant women was followed from gestational weeks 5 to 13, 20 to 26, and 30 to 36. Blood samples were collected at the three visits after 12 h of fasting. Fatty acid concentrations were determined using fast gas-liquid chromatography. Plasma adiponectin (μg/mL) and leptin (ng/dL) concentrations were evaluated using enzyme-linked immunosorbent assay kits. Statistical analyses included median adipokine concentrations according to the tertiles of fatty acid distribution and multiple linear mixed-effect models adjusted for body mass index, gestational age, total energy intake, alcohol consumption, and smoking.

RESULTS

Women classified in the third SFA concentration tertile had lower median values of adiponectin compared with those in the first tertile ([first trimester: first tertile = 5.36; third tertile = 5.00]; [second trimester: first tertile = 6.39; third tertile = 4.47]; [third trimester: first tertile = 6.46; third tertile = 4.60]). Similar trends were observed for the 14:0, 16:0 and 18:0 fractions. In the multiple longitudinal models, total SFA (β = -41.039; P = 0.008) and 16:0 were negatively associated with plasma adiponectin (16:0, β = -0.511; P = 0.001). Total PUFA ω-6 (β = 28.961; P = 0.002) and 18:2 ω-6 (β = 0.259, P = 0.006) were positively associated with the adiponectin. Total SFA (β = 0.110, P = 0.007), 14:0 (β = 0.072, P = 0.011), and 20:3 ω-6 (β = 0.039; P = 0.035) were positively associated with plasma leptin.

CONCLUSIONS

Total serum SFA and the 16:0 fraction were negatively associated with plasma adiponectin and positively associated with leptin concentrations. Total ω-6 PUFA was positively associated only with plasma adiponectin concentrations throughout pregnancy.

摘要

目的

本研究旨在调查孕期血清中总饱和脂肪酸（SFA）、多不饱和脂肪酸（PUFA）及其组分的浓度是否与血浆脂联素和瘦素浓度相关。

方法

对201名孕妇进行前瞻性队列研究，随访时间为孕5至13周、20至26周以及30至36周。在三次访视时，于禁食12小时后采集血样。采用快速气液色谱法测定脂肪酸浓度。使用酶联免疫吸附测定试剂盒评估血浆脂联素（μg/mL）和瘦素（ng/dL）浓度。统计分析包括根据脂肪酸分布三分位数划分的中位脂肪因子浓度，以及针对体重指数、孕周、总能量摄入、饮酒量和吸烟情况进行调整的多元线性混合效应模型。

结果

与处于SFA浓度第一三分位数的女性相比，处于第三三分位数的女性脂联素中位值较低（[孕早期：第一三分位数 = 5.36；第三三分位数 = 5.00]；[孕中期：第一三分位数 = 6.39；第三三分位数 = 4.47]；[孕晚期：第一三分位数 = 6.46；第三三分位数 = 4.60]）。在14:0、16:0和18:0组分中也观察到类似趋势。在多元纵向模型中，总SFA（β = -41.039；P = 0.008）和16:0与血浆脂联素呈负相关（16:0，β = -0.511；P = 0.001）。总PUFA ω-6（β = 28.961；P = 0.002）和18:2 ω-6（β = 0.259，P = 0.006）与脂联素呈正相关。总SFA（β = 0.110，P = 0.007）、14:0（β = 0.072，P = 0.011）和20:3 ω-6（β = 0.039；P = 0.035）与血浆瘦素呈正相关。