Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Rio de Janeiro Federal University, Rio de Janeiro, Brazil.
Division of Women's Health, King's College London, St Thomas' Hospital, London, UK.
Sci Rep. 2017 Apr 11;7(1):804. doi: 10.1038/s41598-017-00941-y.
The change in maternal lipid, leptin and adiponectin concentrations during pregnancy and infant birth weight (BW) is still poorly characterized. Thus, the aim of the study was to evaluate the association of maternal lipids, leptin and adiponectin throughout pregnancy with large-for-gestational-age (LGA) births and BW z-score. A prospective cohort of 199 mothers was followed during pregnancy in Rio de Janeiro, Brazil. The statistical analyses comprised multiple logistic and linear regression. Women delivered 36 LGA and 11 small-for-gestational-age newborns. HDL-c rate of change throughout pregnancy was negatively associated with BW z-score (β = -1.99; p = 0.003) and the delivery of a LGA newborn (OR = 0.02; p = 0.043). Pregnancy baseline concentration of log leptin was positively associated (OR = 3.92; p = 0.025) with LGA births. LDL-c rate of change throughout pregnancy was positively associated with BW z-score (β = 0.31; p = 0.004). Log triglycerides and log adiponectin were not significantly associated with BW z-score or LGA birth. In conclusion, a higher log leptin pregnancy baseline concentration and a lower HDL-c rate of change during pregnancy were associated with higher odds of having a LGA newborn. These maternal biomarkers are important to foetal growth and could be used in prenatal care as an additional strategy to screen women at risk of inadequate BW.
怀孕期间母体脂质、瘦素和脂联素浓度的变化以及婴儿出生体重（BW）仍然知之甚少。因此，本研究旨在评估整个孕期母体脂质、瘦素和脂联素与巨大儿（LGA）出生和 BW z 评分的关系。一项前瞻性队列研究在巴西里约热内卢对 199 名孕妇进行了孕期随访。统计分析包括多重逻辑回归和线性回归。共有 36 名孕妇分娩 LGA 新生儿，11 名孕妇分娩 SGA 新生儿。整个孕期 HDL-c 浓度的变化与 BW z 评分呈负相关（β=-1.99；p=0.003），与 LGA 新生儿的分娩呈负相关（OR=0.02；p=0.043）。妊娠基线瘦素的对数浓度与 LGA 分娩呈正相关（OR=3.92；p=0.025）。整个孕期 LDL-c 浓度的变化与 BW z 评分呈正相关（β=0.31；p=0.004）。log 甘油三酯和 log 脂联素与 BW z 评分或 LGA 出生无显著相关性。总之，妊娠基线时较高的 log 瘦素浓度和较低的 HDL-c 浓度变化与 LGA 新生儿的高风险相关。这些母体生物标志物与胎儿生长有关，可作为产前保健的额外策略，用于筛查 BW 不足的高危妇女。
