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通过纳米颗粒表面功能与蛋白质冠层的相互作用调节巨噬细胞识别

Regulation of Macrophage Recognition through the Interplay of Nanoparticle Surface Functionality and Protein Corona.

作者信息

Saha Krishnendu, Rahimi Mehran, Yazdani Mahdieh, Kim Sung Tae, Moyano Daniel F, Hou Singyuk, Das Ridhha, Mout Rubul, Rezaee Farhad, Mahmoudi Morteza, Rotello Vincent M

机构信息

Department of Chemistry, University of Massachusetts Amherst , 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.

Department of Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen , Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.

出版信息

ACS Nano. 2016 Apr 26;10(4):4421-30. doi: 10.1021/acsnano.6b00053. Epub 2016 Apr 11.

DOI:10.1021/acsnano.6b00053
PMID:27040442
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5696791/
Abstract

Using a family of cationic gold nanoparticles (NPs) with similar size and charge, we demonstrate that proper surface engineering can control the nature and identity of protein corona in physiological serum conditions. The protein coronas were highly dependent on the hydrophobicity and arrangement of chemical motifs on NP surface. The NPs were uptaken in macrophages in a corona-dependent manner, predominantly through recognition of specific complement proteins in the NP corona. Taken together, this study shows that surface functionality can be used to tune the protein corona formed on NP surface, dictating the interaction of NPs with macrophages.

摘要

使用一系列尺寸和电荷相似的阳离子金纳米颗粒（NPs），我们证明了适当的表面工程可以在生理血清条件下控制蛋白质冠的性质和特性。蛋白质冠高度依赖于NP表面化学基序的疏水性和排列。NPs以冠依赖的方式被巨噬细胞摄取，主要是通过识别NP冠中的特定补体蛋白。综上所述，本研究表明表面功能可用于调节在NP表面形成的蛋白质冠，从而决定NPs与巨噬细胞的相互作用。

相似文献

[1]
Regulation of Macrophage Recognition through the Interplay of Nanoparticle Surface Functionality and Protein Corona.

ACS Nano. 2016-4-26

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Probing the Protein-Nanoparticle Interface: The Role of Aromatic Substitution Pattern on Affinity.

Supramol Chem. 2015

[2]
Impact of protein pre-coating on the protein corona composition and nanoparticle cellular uptake.

Biomaterials. 2015-10-9

[3]
Exploiting the novel properties of protein coronas: emerging applications in nanomedicine.

Nanomedicine (Lond). 2015-5

[4]
Ex situ evaluation of the composition of protein corona of intravenously injected superparamagnetic nanoparticles in rats.

Nanoscale. 2014-10-7

[5]
Non-viral vectors for gene-based therapy.

Nat Rev Genet. 2014-7-15

[6]
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity.

Nat Commun. 2014-6-27

[7]
Protein corona composition of superparamagnetic iron oxide nanoparticles with various physico-chemical properties and coatings.

Sci Rep. 2014-5-21

[8]
Protein coronas on gold nanorods passivated with amphiphilic ligands affect cytotoxicity and cellular response to penicillin/streptomycin.

ACS Nano. 2014-4-23

[9]
Uptake and transfection efficiency of PEGylated cationic liposome-DNA complexes with and without RGD-tagging.

Biomaterials. 2014-6

[10]
Gold nanoparticles for nucleic acid delivery.

Mol Ther. 2014-6

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