Majithia Neil, Smith Thomas J, Coyne Patrick J, Abdi Salahadin, Pachman Deirdre R, Lachance Daniel, Shelerud Randy, Cheville Andrea, Basford Jeffrey R, Farley David, O'Neill Carrie, Ruddy Kathryn J, Sparadeo Frank, Beutler Andreas, Loprinzi Charles L
Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins, Baltimore, MD, USA.
Support Care Cancer. 2016 Jun;24(6):2807-14. doi: 10.1007/s00520-016-3177-3. Epub 2016 Apr 4.
Chronic pain is a widespread and debilitating condition, encountered by physicians in a variety of practice settings. Although many pharmacologic and behavioral strategies exist for the management of this condition, treatment is often unsatisfactory. Scrambler Therapy is a novel, non-invasive pain modifying technique that utilizes trans-cutaneous electrical stimulation of pain fibers with the intent of re-organizing maladaptive signaling pathways. This review was conducted to further evaluate what is known regarding the mechanisms and mechanics of Scrambler Therapy and to investigate the preliminary data pertaining to the efficacy of this treatment modality.
The PubMed/Medline, SCOPUS, EMBASE, and Google Scholar databases were searched for all articles published on Scrambler Therapy prior to November 2015. All case studies and clinical trials were evaluated and reported in a descriptive manner.
To date, 20 reports, of varying scientific quality, have been published regarding this device; all but one small study, published only as an abstract, provided results that appear positive.
The positive findings from preliminary studies with Scrambler Therapy support that this device provides benefit for patients with refractory pain syndromes. Larger, randomized studies are required to further evaluate the efficacy of this approach.
慢性疼痛是一种普遍存在且使人衰弱的病症，在各种临床环境中医生都会遇到。尽管有许多药物和行为策略可用于治疗这种病症，但治疗效果往往不尽人意。扰频器疗法是一种新型的非侵入性疼痛调节技术，它利用经皮电刺激疼痛纤维，旨在重新组织适应不良的信号通路。进行这项综述是为了进一步评估关于扰频器疗法的机制和原理的已知信息，并调查与这种治疗方式疗效相关的初步数据。
检索了PubMed/Medline、SCOPUS、EMBASE和谷歌学术数据库，查找2015年11月之前发表的所有关于扰频器疗法的文章。对所有病例研究和临床试验进行了评估，并以描述性方式进行了报告。
迄今为止，已发表了20篇关于该设备的报告，科学质量各不相同；除了一项仅作为摘要发表的小型研究外，其他所有研究的结果似乎都是积极的。
扰频器疗法初步研究的积极结果表明，该设备对难治性疼痛综合征患者有益。需要进行更大规模的随机研究来进一步评估这种方法 的疗效。
