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通过区域选择性[3+2]环加成反应合成2-芳基-2H-四唑

Synthesis of 2-aryl-2H-tetrazoles via a regioselective [3+2] cycloaddition reaction.

作者信息

Patouret Remi, Kamenecka Theodore M

机构信息

The Scripps Research Institute, Scripps Florida, Department of Molecular Therapeutics, 130 Scripps Way #A2A, Jupiter, FL 33458, USA.

出版信息

Tetrahedron Lett. 2016 Apr 6;57(14):1597-1599. doi: 10.1016/j.tetlet.2016.02.102.

DOI:10.1016/j.tetlet.2016.02.102
PMID:27041776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4810784/
Abstract

A regioselective cycloaddition reaction of arenediazonium salts with trimethylsilyldiazomethane is reported. A series of 2-aryltetrazoles were obtained in good to moderate yields with wide functional group compatibility. Furthermore, this cycloaddition reaction opens the way to build up the versatile intermediate 2-aryl-5-bromotetrazole.

摘要

报道了芳基重氮盐与三甲基硅基重氮甲烷的区域选择性环加成反应。以良好至中等的产率得到了一系列具有广泛官能团兼容性的2-芳基四唑。此外，这种环加成反应为构建通用中间体2-芳基-5-溴四唑开辟了道路。

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