大鼠脾阴虚病理模型的初步研究
Preliminary study on the pathological model of Piyinxu in rats.
作者信息
Chen D Z, Wei M X
机构信息
De-Zhen Chen, Mu-Xin Wei, Department of Traditional Chinese Medicine, The First College of Clinical Medicine, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
出版信息
World J Gastroenterol. 1997 Jun 15;3(2):120. doi: 10.3748/wjg.v3.i2.120.
AIM
To study the method of constructing a pathological model of Piyinxu (spleen-yin deficiency) using Sprague-Dawley rats and to make preliminary observations.
METHODS
Folium sennae (0.8 g) and tabellae thyroidei (80 mg) were given daily by stomach feeding to each rat for 12 d to establish the pathological model of Piyinxu. The activity of the rats and the characteristics of their stool were observed.
RESULTS
We observed not only the symptoms of Pixu, such as diarrhea, poor appetite, abdominal distention, weight loss, but also Yinxuneire (endogenous heat), such as increase in water drinking, nervousness, and restlessness. These symptoms were all different from that of the control group of Piyangxu (spleen-yang deficiency).
CONCLUSION
Combining folium sennae and tabellae thyroidei is an effective method for establishing a pathological model of Piyinxu.
目的
研究运用斯普拉格-道利大鼠构建脾阴虚病理模型的方法并进行初步观察。
方法
每日给每只大鼠经胃灌喂番泻叶（0.8克）和甲状腺片（80毫克），持续12天以建立脾阴虚病理模型。观察大鼠的活动情况及其粪便特征。
结果
我们不仅观察到脾虚症状，如腹泻、食欲不振、腹胀、体重减轻，还观察到阴虚内热症状，如饮水量增加、烦躁、不安。这些症状均与脾阳虚对照组不同。
结论
番泻叶与甲状腺片联用是建立脾阴虚病理模型的有效方法。
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