Chen D Z, Wei M X
De-Zhen Chen, Mu-Xin Wei, Department of Traditional Chinese Medicine, The First College of Clinical Medicine, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
World J Gastroenterol. 1997 Jun 15;3(2):120. doi: 10.3748/wjg.v3.i2.120.
To study the method of constructing a pathological model of Piyinxu (spleen-yin deficiency) using Sprague-Dawley rats and to make preliminary observations.
Folium sennae (0.8 g) and tabellae thyroidei (80 mg) were given daily by stomach feeding to each rat for 12 d to establish the pathological model of Piyinxu. The activity of the rats and the characteristics of their stool were observed.
We observed not only the symptoms of Pixu, such as diarrhea, poor appetite, abdominal distention, weight loss, but also Yinxuneire (endogenous heat), such as increase in water drinking, nervousness, and restlessness. These symptoms were all different from that of the control group of Piyangxu (spleen-yang deficiency).
Combining folium sennae and tabellae thyroidei is an effective method for establishing a pathological model of Piyinxu.
研究运用斯普拉格-道利大鼠构建脾阴虚病理模型的方法并进行初步观察。
每日给每只大鼠经胃灌喂番泻叶（0.8克）和甲状腺片（80毫克），持续12天以建立脾阴虚病理模型。观察大鼠的活动情况及其粪便特征。
我们不仅观察到脾虚症状，如腹泻、食欲不振、腹胀、体重减轻，还观察到阴虚内热症状，如饮水量增加、烦躁、不安。这些症状均与脾阳虚对照组不同。
番泻叶与甲状腺片联用是建立脾阴虚病理模型的有效方法。
