围手术期循环肿瘤细胞检测：当前观点
Perioperative circulating tumor cell detection: Current perspectives.
作者信息
Kaifi Jussuf T, Li Guangfu, Clawson Gary, Kimchi Eric T, Staveley-O'Carroll Kevin F
机构信息
a Hugh E. Stephenson Jr., M.D. , Department of Surgery , University of Missouri , Columbia , MO , USA.
b Ellis Fischel Cancer Center , University of Missouri , Columbia , MO , USA.
出版信息
Cancer Biol Ther. 2016 Aug 2;17(8):859-69. doi: 10.1080/15384047.2016.1167296. Epub 2016 Apr 5.
Abstract
Primary cancer resections and in selected cases surgical metastasectomies significantly improve survival, however many patients develop recurrences. Circulating tumor cells (CTCs) function as an independent marker that could be used in the prognostication of different cancers. Sampling of blood and bone marrow compartments during cancer resections is a unique opportunity to increase individual tumor cell capture efficiency. This review will address the diagnostic and therapeutic potentials of perioperative tumor isolation and highlight the focus of future studies on characterization of single disseminated cancer cells to identify targets for molecular therapy and immune escape mechanisms.
摘要
原发性癌症切除术以及在某些特定病例中的手术性转移灶切除术可显著提高生存率，然而许多患者会出现复发。循环肿瘤细胞（CTC）作为一种独立标志物，可用于不同癌症的预后评估。在癌症切除术中对血液和骨髓腔室进行采样是提高单个肿瘤细胞捕获效率的独特机会。本综述将探讨围手术期肿瘤分离的诊断和治疗潜力，并强调未来研究在单个播散癌细胞特征分析方面的重点，以确定分子治疗靶点和免疫逃逸机制。
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J Thorac Cardiovasc Surg. 2016 Mar;151(3):852-858. doi: 10.1016/j.jtcvs.2015.09.126. Epub 2015 Oct 22.
2
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BMC Cancer. 2015 Oct 24;15:797. doi: 10.1186/s12885-015-1779-7.
3
Circulating Epithelial Cells in Patients with Pancreatic Lesions: Clinical and Pathologic Findings.胰腺病变患者的循环上皮细胞：临床和病理结果
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8
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