用于基于干细胞的组织工程与再生的富血小板血液衍生物
Platelet-Rich Blood Derivatives for Stem Cell-Based Tissue Engineering and Regeneration.
作者信息
Masoudi Elham, Ribas João, Kaushik Gaurav, Leijten Jeroen, Khademhosseini Ali
机构信息
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
出版信息
Curr Stem Cell Rep. 2016 Mar;2(1):33-42. doi: 10.1007/s40778-016-0034-8. Epub 2016 Feb 13.
Abstract
Platelet rich blood derivatives have been widely used in different fields of medicine and stem cell based tissue engineering. They represent natural cocktails of autologous growth factor, which could provide an alternative for recombinant protein based approaches. Platelet rich blood derivatives, such as platelet rich plasma, have consistently shown to potentiate stem cell proliferation, migration, and differentiation. Here, we review the spectrum of platelet rich blood derivatives, discuss their current applications in tissue engineering and regenerative medicine, reflect on their effect on stem cells, and highlight current translational challenges.
摘要
富含血小板的血液衍生物已广泛应用于医学的不同领域和基于干细胞的组织工程。它们代表了自体生长因子的天然混合物，可为基于重组蛋白的方法提供替代方案。富含血小板的血液衍生物，如富血小板血浆，一直显示出能增强干细胞的增殖、迁移和分化。在此，我们综述富含血小板的血液衍生物的种类，讨论它们在组织工程和再生医学中的当前应用，思考它们对干细胞的影响，并突出当前的转化挑战。
相似文献
1
Platelet-Rich Blood Derivatives for Stem Cell-Based Tissue Engineering and Regeneration.用于基于干细胞的组织工程与再生的富血小板血液衍生物
Curr Stem Cell Rep. 2016 Mar;2(1):33-42. doi: 10.1007/s40778-016-0034-8. Epub 2016 Feb 13.
2
Blood Plasma Derivatives for Tissue Engineering and Regenerative Medicine Therapies.血浆衍生物在组织工程和再生医学治疗中的应用。
Tissue Eng Part B Rev. 2018 Dec;24(6):454-462. doi: 10.1089/ten.TEB.2018.0008. Epub 2018 Oct 5.
3
Platelet-Rich Plasma in Tissue Engineering: Hype and Hope.组织工程中的富血小板血浆：炒作与希望
Eur Surg Res. 2018;59(3-4):265-275. doi: 10.1159/000492415. Epub 2018 Sep 21.
4
Adipose-derived stem cells and platelet-rich plasma: the keys to functional periodontal tissue engineering.脂肪干细胞和富含血小板的血浆：功能性牙周组织工程的关键。
Curr Stem Cell Res Ther. 2013 Sep;8(5):400-6. doi: 10.2174/1574888x113089990055.
5
Combined treatment with platelet-rich plasma and insulin favours chondrogenic and osteogenic differentiation of human adipose-derived stem cells in three-dimensional collagen scaffolds.富含血小板血浆与胰岛素联合治疗有利于人脂肪来源干细胞在三维胶原支架中的软骨生成和成骨分化。
J Tissue Eng Regen Med. 2017 Aug;11(8):2398-2410. doi: 10.1002/term.2139. Epub 2016 Apr 14.
6
Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration.富含血小板血浆衍生生长因子有助于肌肉骨骼再生中的干细胞分化。
Front Chem. 2017 Oct 31;5:89. doi: 10.3389/fchem.2017.00089. eCollection 2017.
7
Platelet-rich plasma and regenerative dentistry.富血小板血浆与再生牙科。
Aust Dent J. 2020 Jun;65(2):131-142. doi: 10.1111/adj.12754. Epub 2020 Mar 24.
8
Adipose-Derived Stromal Vascular Fraction Cells and Platelet-Rich Plasma: Basic and Clinical Implications for Tissue Engineering Therapies in Regenerative Surgery.脂肪来源的基质血管成分细胞与富含血小板血浆：再生外科组织工程治疗的基础与临床意义
Methods Mol Biol. 2018;1773:107-122. doi: 10.1007/978-1-4939-7799-4_9.
9
Progress of Platelet Derivatives for Cartilage Tissue Engineering.用于软骨组织工程的血小板衍生物研究进展
Front Bioeng Biotechnol. 2022 Jun 16;10:907356. doi: 10.3389/fbioe.2022.907356. eCollection 2022.
10
Concise Review: The Use of Adipose-Derived Stromal Vascular Fraction Cells and Platelet Rich Plasma in Regenerative Plastic Surgery.简要综述：脂肪源性基质血管成分细胞和富血小板血浆在整形修复外科中的应用
Stem Cells. 2017 Jan;35(1):117-134. doi: 10.1002/stem.2498. Epub 2016 Oct 24.
引用本文的文献
1
Emerging therapeutic benefit of platelet-rich fibrin as novel platelet concentrates in tissue engineering.富血小板纤维蛋白作为新型血小板浓缩物在组织工程中的新兴治疗益处。
Glob Cardiol Sci Pract. 2024 Nov 1;2024(5):e202446. doi: 10.21542/gcsp.2024.46.
2
Clinical and Molecular Impact of Advanced Platelet-Rich Fibrin on Pain, Swelling, and Distal Periodontal Status of Mandibular Second Molars After Mandibular Third-Molar Extraction.富含血小板纤维蛋白高级制剂对下颌第三磨牙拔除后下颌第二磨牙疼痛、肿胀及牙周远端状况的临床和分子影响
Medicina (Kaunas). 2024 Dec 14;60(12):2062. doi: 10.3390/medicina60122062.
3
Comparison of Corneal Epitheliotrophic Factors of Undiluted Autologous Platelet-Rich Plasma and Autologous Serum Eye Drops for Dry Eye Disease.未稀释的自体富血小板血浆与自体血清滴眼液治疗干眼病的角膜上皮营养因子比较
Ophthalmol Ther. 2025 Feb;14(2):363-377. doi: 10.1007/s40123-024-01082-y. Epub 2024 Dec 20.
4
Revolutionizing medicine: recent developments and future prospects in stem-cell therapy.医学革命：干细胞治疗的最新进展与未来前景
Int J Surg. 2024 Dec 1;110(12):8002-8024. doi: 10.1097/JS9.0000000000002109.
5
Efficacy of 100% autologous platelet-rich plasma and 100% autologous serum in dry eye disease: a randomised controlled trial.100%自体富血小板血浆和 100%自体血清治疗干眼症的疗效：一项随机对照试验。
BMJ Open Ophthalmol. 2024 Oct 8;9(1):e001857. doi: 10.1136/bmjophth-2024-001857.
6
Clinical and ultrasonographic evaluation of efficacy and safety of intralesional injection of autologous platelet-rich plasma in morphea: A comparative case series.局部注射自体富血小板血浆治疗硬斑病的疗效及安全性的临床和超声评估：一项对比病例系列研究
J Scleroderma Relat Disord. 2024 Jun;9(2):162-168. doi: 10.1177/23971983231222664. Epub 2024 Jan 23.
7
Platelet Power: Revitalizing Endodontics With Scaffolds.血小板力量：用支架重振牙髓病学。
Cureus. 2024 May 20;16(5):e60691. doi: 10.7759/cureus.60691. eCollection 2024 May.
8
Dental pulp regeneration strategies: A review of status quo and recent advances.牙髓再生策略：现状与最新进展综述
Bioact Mater. 2024 May 7;38:258-275. doi: 10.1016/j.bioactmat.2024.04.031. eCollection 2024 Aug.
9
Clinical observation of ultraviolet therapy combined with autologous platelet-rich plasma in the treatment of chronic refractory wounds.紫外线疗法联合自体富血小板血浆治疗慢性难愈性创面的临床观察
Int Wound J. 2024 Apr;21(4):e14746. doi: 10.1111/iwj.14746.
10
Intravesical instillation of platelet-rich plasma for treatment of interstitial cystitis/bladder pain syndrome: A pilot study.膀胱内灌注富血小板血浆治疗间质性膀胱炎/膀胱疼痛综合征：一项初步研究。
Curr Urol. 2024 Mar;18(1):49-54. doi: 10.1097/CU9.0000000000000156. Epub 2022 Oct 19.
本文引用的文献
1
Platelet-rich plasma releasate differently stimulates cellular commitment toward the chondrogenic lineage according to concentration.富含血小板血浆释放物根据浓度不同刺激细胞向软骨形成谱系的定向分化。
J Tissue Eng. 2015 Jul 7;6:2041731415594127. doi: 10.1177/2041731415594127. eCollection 2015 Jan-Dec.
2
Platelet-Rich Plasma Increases Growth and Motility of Adipose Tissue-Derived Mesenchymal Stem Cells and Controls Adipocyte Secretory Function.富血小板血浆可促进脂肪组织来源间充质干细胞的生长和迁移，并调控脂肪细胞的分泌功能。
J Cell Biochem. 2015 Oct;116(10):2408-18. doi: 10.1002/jcb.25235.
3
Platelet-rich plasma increases proliferation of tendon cells by modulating Stat3 and p27 to up-regulate expression of cyclins and cyclin-dependent kinases.富含血小板血浆通过调节Stat3和p27来上调细胞周期蛋白和细胞周期蛋白依赖性激酶的表达，从而增加肌腱细胞的增殖。
Cell Prolif. 2015 Aug;48(4):413-20. doi: 10.1111/cpr.12189. Epub 2015 May 25.
4
Effect of activated autologous platelet-rich plasma on proliferation and osteogenic differentiation of human adipose-derived stem cells in vitro.激活的自体富血小板血浆对人脂肪来源干细胞体外增殖和成骨分化的影响。
Am J Transl Res. 2015 Feb 15;7(2):257-70. eCollection 2015.
5
Principles and Methods of Preparation of Platelet-Rich Plasma: A Review and Author's Perspective.富血小板血浆的制备原理与方法：综述及作者观点
J Cutan Aesthet Surg. 2014 Oct-Dec;7(4):189-97. doi: 10.4103/0974-2077.150734.
6
Platelet-Rich Plasma Increases Anti-inflammatory Markers in a Human Coculture Model for Osteoarthritis.富血小板血浆在骨关节炎人类共培养模型中增加抗炎标志物。
Am J Sports Med. 2015 Jun;43(6):1474-84. doi: 10.1177/0363546515570463. Epub 2015 Feb 25.
7
Platelet-rich concentrates differentially release growth factors and induce cell migration in vitro.富含血小板的浓缩物在体外可不同程度地释放生长因子并诱导细胞迁移。
Clin Orthop Relat Res. 2015 May;473(5):1635-43. doi: 10.1007/s11999-015-4192-2.
8
Platelet-rich plasma modulates the secretion of inflammatory/angiogenic proteins by inflamed tenocytes.富含血小板血浆调节炎症性肌腱细胞分泌炎症/血管生成蛋白。
Clin Orthop Relat Res. 2015 May;473(5):1624-34. doi: 10.1007/s11999-015-4179-z.
9
Platelet derivatives in regenerative medicine: an update.再生医学中的血小板衍生物：最新进展
Transfus Med Rev. 2015 Jan;29(1):52-61. doi: 10.1016/j.tmrv.2014.11.001. Epub 2014 Nov 18.
10
Administration of human platelet-rich plasma reduces infarction volume and improves motor function in adult rats with focal ischemic stroke.给予富含人血小板血浆可减少成年局灶性缺血性中风大鼠的梗死体积并改善运动功能。
Brain Res. 2015 Jan 12;1594:267-73. doi: 10.1016/j.brainres.2014.10.035. Epub 2014 Nov 6.
Zotero 插件