来自西部地区的墨西哥梅斯蒂索人的23个STR基因座（PowerPlex® Fusion系统）的群体数据。
Population data of 23 STR loci (PowerPlex® Fusion System) in Mexican Mestizos from the West Region.
作者信息
Aguilar-Velázquez J A, Martínez-Cortés G, Inclán-Sánchez A, Romero-Rentería O, Díaz-Navarro X X, Rangel-Villalobos H
机构信息
Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara (CUCiénega-UdeG), Av. Universidad #1115, Col. Paso Blanco, Ocotlán, Jalisco, CP 47810, Mexico.
Laboratorio de Genética Forense, Procuraduría de Justicia del Distrito Federal, México, DF, Mexico.
出版信息
Int J Legal Med. 2016 Nov;130(6):1489-1491. doi: 10.1007/s00414-016-1361-0. Epub 2016 Apr 5.
We analyzed 238 unrelated Mestizo (admixed) individuals from the West region of Mexico with the PowerPlex® Fusion System (Promega Corp.). Allele frequencies and forensic parameters were estimated for the 23 STRs included in this kit. Hardy-Weinberg equilibrium by locus and non-association between pair of loci were demonstrated by exact tests in this population. The combined PE and PD offered by this HID kit were ≥0.9999999986, representing a substantial improvement with respect to those previously offered by 15 STR systems. Interpopulation comparison by AMOVA tests demonstrated low but significant differences among Mexican Mestizos from West, Center, and Northeast regions (Fst = 0.01558; p = 0.0000), similar to the observed among three main ethnic groups from USA (Fst = 0.02048; p = 0.0000). This finding is consistent with the contrary clines of European and Amerindian ancestries described throughout the Mexican territory for Mestizos, the largest population (~90 %) in this country.
我们使用PowerPlex® Fusion System（普洛麦格公司）对来自墨西哥西部地区的238名无亲缘关系的梅斯蒂索人（混血儿）个体进行了分析。对该试剂盒中包含的23个短串联重复序列（STR）的等位基因频率和法医学参数进行了估计。通过精确检验证明了该群体中各基因座的哈迪-温伯格平衡以及基因座对之间的非关联性。该人类身份识别（HID）试剂盒提供的累积个体识别率（PE）和累积排除率（PD）≥0.9999999986，相对于之前15个STR系统所提供的结果有了显著提高。通过分子方差分析（AMOVA）测试进行的群体间比较表明，来自墨西哥西部、中部和东北部地区的梅斯蒂索人之间存在低但显著的差异（Fst = 0.01558；p = 0.0000），这与在美国三个主要种族群体中观察到的情况类似（Fst = 0.02048；p = 0.0000）。这一发现与墨西哥境内梅斯蒂索人（该国最大的群体，约占90%）中欧洲和美洲印第安人血统的相反渐变情况一致。
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