Zhao Yu, Liu Zhi-Gang, Tang Jiao, Zou Ren-Fang, Chen Xiao-Yan, Jiang Guan-Min, Qiu Yan-Fang, Wang Hui
Key Laboratory of Translational Radiation Oncology, Department of Radiation Oncology, Changsha, Hunan, People's Republic of China.
Department of Pathology, Central South University, Changsha, Hunan, People's Republic of China.
Onco Targets Ther. 2016 Mar 21;9:1671-7. doi: 10.2147/OTT.S101344. eCollection 2016.
The aim of the study was to detect the expression of Sox10 in human nasopharyngeal carcinoma (NPC) and investigate the relationship between its expression and the clinicopathological characteristics of NPC patients.
Tumor specimens (n=105) were retrospectively collected from patients with NPC diagnosed between 2004 and 2005 who presented at Hunan Cancer Hospital. Immunohistochemistry analyses were performed to characterize the expression of Sox10 in NPC. Kaplan-Meier survival and Cox regression analyses were employed to evaluate the prognosis of 105 NPC patients.
The results showed that Sox10 was markedly overexpressed in human NPC tissues. Analysis of clinicopathological parameters showed that high Sox10 expression was significantly correlated with the clinical stage (P=0.032), T classification (P=0.034), and lymph node metastasis (P=0.03). Cox regression analyses further showed that Sox10 expression was an independent prognostic factor for overall survival (P=0.005). This is the first time Sox10 has shown its importance in predicting NPC progressiveness and survival outcomes.
Sox10 serves as a potential biomarker for NPC patients. It may hopefully become a novel therapeutic target for NPC patients.
本研究旨在检测Sox10在人类鼻咽癌（NPC）中的表达，并探讨其表达与NPC患者临床病理特征之间的关系。
回顾性收集2004年至2005年期间在湖南省肿瘤医院就诊的NPC患者的肿瘤标本（n = 105）。采用免疫组织化学分析来表征Sox10在NPC中的表达。采用Kaplan-Meier生存分析和Cox回归分析来评估105例NPC患者的预后。
结果显示，Sox10在人类NPC组织中明显过表达。临床病理参数分析表明，Sox10高表达与临床分期（P = 0.032）、T分级（P = 0.034）和淋巴结转移（P = 0.03）显著相关。Cox回归分析进一步表明，Sox10表达是总生存期的独立预后因素（P = 0.005）。这是Sox10首次显示出其在预测NPC进展和生存结果方面的重要性。
Sox10可作为NPC患者的潜在生物标志物。有望成为NPC患者的新型治疗靶点。
