Sun Yongyan, Shi Zhenhua, Lian Huiyong, Cai Peng
Physical Environment Laboratory, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Avenue, Xiamen, 361021, People's Republic of China.
University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, People's Republic of China.
Clin Transl Med. 2016 Mar;5(1):14. doi: 10.1186/s40169-016-0094-5. Epub 2016 Apr 6.
Cancer, as a leading cause of death, has attracted enormous public attention. Reprogramming of cellular energy metabolism is deemed to be one of the principal hallmarks of cancer. In this article, we reviewed the mutual relationships among environmental pollution factors, energy metabolic dysfunction, and various cancers. We found that most environmental pollution factors could induce cancers mainly by disturbing the energy metabolism. By triggering microenvironment alteration, energy metabolic dysfunction can be treated as a factor in carcinogenesis. Thus, we put forward that energy metabolism might be as a key point for studying carcinogenesis and tumor development to propose new methods for cancer prevention and therapy.
癌症作为主要死因之一，已引起公众的广泛关注。细胞能量代谢重编程被认为是癌症的主要特征之一。在本文中，我们综述了环境污染因素、能量代谢功能障碍与各种癌症之间的相互关系。我们发现，大多数环境污染因素主要通过干扰能量代谢来诱发癌症。通过引发微环境改变，能量代谢功能障碍可被视为致癌因素之一。因此，我们提出能量代谢可能是研究致癌作用和肿瘤发展的关键点，从而为癌症预防和治疗提供新方法。
