Oświęcimska Joanna, Suwała Andrzej, Świętochowska Elżbieta, Ostrowska Zofia, Gorczyca Piotr, Ziora-Jakutowicz Karolina, Machura Edyta, Szczepańska Maria, Hyla-Klekot Lidia, Kukla Michał, Ziora Dariusz, Ziora Katarzyna
J Pediatr Endocrinol Metab. 2016 Jun 1;29(6):681-6. doi: 10.1515/jpem-2015-0390.
Vaspin (VASP) is a protein detected in pre- and mature adipocytes, the production and secretion of which may be conditioned by nutrition status. VASP may also play a role in the regulation of food intake. Since to date, there are no available studies on serum vaspin concentrations in patients with anorexia nervosa (AN), the aim of our study is to assess serum vaspin concentrations in girls with AN in comparison to healthy subjects and determine its relationship with body weight, body masss index (BMI) and insulin.
In this cross-sectional study vaspin serum concentrations were evaluated using a commercially available ELISA kit in 47 Polish girls hospitalized due to restrictive AN and 39 healthy controls (H).
The mean serum concentration of VASP in girls with AN was significantly higher than in the H group. These differences were also noted after adjustment for body masss index-standard deviation score (BMI-SDS), the homeostatic model assessment-insulin resistance (HOMA-IR) index and insulin levels. There were no statistically significant correlations between the serum concentrations of VASP and body mass, BMI, BMI-SDS, insulin and HOMA-IR in the AN or healthy group.
Serum vaspin levels in lean subjects are regulated in different mechanisms than previously reported in obesity. It should be established if elevated serum vaspin levels in girls with AN may contribute to low food intake in these patients.
内脏脂肪素（VASP）是一种在前脂肪细胞和成熟脂肪细胞中检测到的蛋白质，其产生和分泌可能受营养状况的影响。VASP也可能在食物摄入调节中发挥作用。由于迄今为止，尚无关于神经性厌食症（AN）患者血清内脏脂肪素浓度的研究，我们研究的目的是评估AN女孩与健康受试者相比的血清内脏脂肪素浓度，并确定其与体重、体重指数（BMI）和胰岛素的关系。
在这项横断面研究中，使用市售ELISA试剂盒评估了47名因限制性AN住院的波兰女孩和39名健康对照（H）的血清内脏脂肪素浓度。
AN女孩的VASP平均血清浓度显著高于H组。在调整体重指数标准差评分（BMI-SDS）、稳态模型评估-胰岛素抵抗（HOMA-IR）指数和胰岛素水平后，也观察到了这些差异。在AN组或健康组中，VASP的血清浓度与体重、BMI、BMI-SDS、胰岛素和HOMA-IR之间均无统计学显著相关性。
消瘦受试者血清内脏脂肪素水平的调节机制与先前报道的肥胖情况不同。AN女孩血清内脏脂肪素水平升高是否会导致这些患者食物摄入量低，有待确定。
