Division of Biology of Civilization-Linked Diseases, Department of Chemistry and Clinical Biochemistry, Poznan University of Medical Sciences, Swiecickiego 6, 60-781 Poznan, Poland.
Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Szpitalna 27/33, 60-572 Poznan, Poland.
Biomed Res Int. 2018 Jun 10;2018:9727509. doi: 10.1155/2018/9727509. eCollection 2018.
The aim of the study was to assess the correlation between the levels of neuropeptide B (NPB), neuropeptide W (NPW), vaspin (VAS), and the total antioxidant status (TAS) in the blood, as well as nutritional status of patients with anorexia nervosa (AN).
The study covered a cohort of 76 female teenagers, including 46 females with extreme AN and 30 healthy peers (CONTR) aged 12-17.
AN persons were characterized by higher (in comparison to CONTR) NPB and VAS concentrations and lower values of TAS levels, body weight, and anthropometric values. Positive correlations between NPB and VAS levels were noted in the AN group (R=0.33; p<0.001) as well as between concentrations of NPW and VAS in the same group (R=0.49; p<0.001). Furthermore, positive correlations existed between NPB and NPW concentrations across the whole studied population (AN+CONTR; R=0.75; p<0.000001), AN (R=0.73; p<0.000001) and CONTR (R=0.90; p<0.0005).
In detailed diagnostics of AN it is worth considering testing NPB and VAS levels.
本研究旨在评估神经肽 B（NPB）、神经肽 W（NPW）、内脂素（VAS）在血液中的水平与厌食症（AN）患者营养状况之间的相关性。
研究纳入了 76 名 12-17 岁的女性青少年，其中 46 名患有极度 AN，30 名健康女性作为对照组（CONTR）。
与对照组相比，AN 患者的 NPB 和 VAS 浓度更高，TAS 水平、体重和人体测量值更低。在 AN 组中，NPB 和 VAS 水平之间存在正相关（R=0.33；p<0.001），在同一组中 NPW 和 VAS 浓度之间也存在正相关（R=0.49；p<0.001）。此外，在整个研究人群（AN+CONTR；R=0.75；p<0.000001）、AN 组（R=0.73；p<0.000001）和对照组（R=0.90；p<0.0005）中，NPB 和 NPW 浓度之间均存在正相关。
在对 AN 的详细诊断中，值得考虑检测 NPB 和 VAS 水平。
