环状RNA_001569靶向miR-145在结直肠癌增殖和侵袭中的新作用
Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer.
作者信息
Xie Huijun, Ren Xiaoli, Xin Sainan, Lan Xiaoliang, Lu Guifeng, Lin Yuan, Yang Shaoshan, Zeng Zhicheng, Liao Wenting, Ding Yan-Qing, Liang Li
机构信息
Department of Pathology, Nanfang Hospital, Guangzhou, Guangdong, China.
Guangdong Province Key Laboratory of Molecular Tumor Pathology, Guangzhou, Guangdong, China.
出版信息
Oncotarget. 2016 May 3;7(18):26680-91. doi: 10.18632/oncotarget.8589.
Circular RNAs (circRNAs), a large class of RNAs, have recently shown huge capabilities as gene regulators in mammals. Some of them bind with microRNAs (miRNAs) and act as natural miRNA sponges to inhibit related miRNAs' activities. Here we showed that hsa_circ_001569 acted as a positive regulator in cell proliferation and invasion of colorectal cancer (CRC). Moreover, hsa_circ_001569 was identified as a sponge of miR-145 and up-regulated miR-145 functional targets E2F5, BAG4 and FMNL2. In CRC tissues, circ_001569 negatively correlated with miR-145, and miR-145 correlated negatively with E2F5, BAG4 and FMNL2 expressions. Our study reveals a novel regulatory mechanism of circ_001569 in cell proliferation and invasion in CRC, provides a comprehensive landscape of circ_001569 that will facilitate further biomarker discoveries in the progression of CRC.
环状RNA（circRNAs）是一大类RNA，最近在哺乳动物中作为基因调控因子展现出巨大潜力。其中一些与微小RNA（miRNAs）结合，充当天然的miRNA海绵，抑制相关miRNAs的活性。在此我们表明，hsa_circ_001569在结直肠癌（CRC）的细胞增殖和侵袭中起正向调节作用。此外，hsa_circ_001569被鉴定为miR-145的海绵，并上调了miR-145的功能靶点E2F5、BAG4和FMNL2。在CRC组织中，circ_001569与miR-145呈负相关，而miR-145与E2F5、BAG4和FMNL2的表达呈负相关。我们的研究揭示了circ_001569在CRC细胞增殖和侵袭中的一种新型调控机制，提供了circ_001569的全面概况，这将有助于在CRC进展中进一步发现生物标志物。
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